Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | PPARA | Q07869 | 2/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18201985 | 0.81 | THRB (0.40) | L3MBTL1SMN1; SMN2CNR2PPARGPPARA | |
| SCHEMBL11293541 | 0.79 | LMNA (0.67) | LMNAL3MBTL1TP53PKMNFKB1 | |
| SCHEMBL7167442 | 0.77 | ALOX5 (0.49) | LMNAL3MBTL1ALOX5MAOB | |
| SCHEMBL6188338 | 0.77 | ALOX5 (0.55) | LMNANR4A1NR4A2NR4A3ALOX5 | |
| SCHEMBL9421418 | 0.77 | LMNA (0.57) | LMNAL3MBTL1SMN1; SMN2PPARGPPARA | |
| Ethylene SCHEMBL27940790 | 0.76 | LMNA (0.62) | LMNAL3MBTL1TP53PKMNFKB1 | |
| SCHEMBL8505924 | 0.75 | LMNA (0.53) | LMNAL3MBTL1SMN1; SMN2NR4A1NR4A2 | |
| SCHEMBL2844054 | 0.75 | LMNA (0.53) | LMNAL3MBTL1SMN1; SMN2NR4A1NR4A2 | |
| SCHEMBL8505922 | 0.75 | LMNA (0.53) | LMNAL3MBTL1SMN1; SMN2NR4A1NR4A2 | |
| SCHEMBL27578695 | 0.74 | ALOX5 (0.52) | LMNAALOX5MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016176473-A1 | APELIN RECEPTOR AGONISTS AND METHODS OF USE THEREOF | SANFORD-BURNHAM MEDICAL RESEARC INSTITUTE (US) | 2016-11-03 | — | — | WO | disclosed |