Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 5/20 | 0.44 |
| ▸ | PAM | P19021 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL872760 | 1.00 | HDAC4 (0.44) | HDAC4PAMMAPTTHRBPSEN1 | |
| SCHEMBL433694 | 0.77 | HSD11B1 (0.54) | ALDH1A1HSD11B1 | |
| SCHEMBL433257 | 0.77 | HSD11B1 (0.54) | ALDH1A1HSD11B1 | |
| SCHEMBL30929499 | 0.73 | HDAC4 (0.44) | HDAC4GAAALDH1A1OPRM1OPRD1 | |
| SCHEMBL15043672 | 0.72 | HDAC4 (0.42) | HDAC4MAPTTHRBPSEN1PSEN2 | |
| SCHEMBL2867660 | 0.71 | HDAC4 (0.65) | HDAC4MAPTTHRBPSEN1PSEN2 | |
| SCHEMBL29567033 | 0.71 | HDAC4 (0.65) | HDAC4MAPTTHRBPSEN1PSEN2 | |
| SCHEMBL15042455 | 0.69 | HDAC4 (0.40) | HDAC4MAPTPSEN1PSEN2APH1B | |
| SCHEMBL625059 | 0.69 | HDAC4 (0.45) | HDAC4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL31580968 | 0.69 | HDAC4 (0.67) | HDAC4MAPTTHRBPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493866-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS | Bristol-Myers Squibb Company (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011059784-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |