Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TYMP | P19971 | 1/20 | 0.38 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6035360 | 0.82 | CYP1A2 (0.44) | DHFRCES1GPR84ALDH1A1HSD17B10 | |
| SCHEMBL30944688 | 0.80 | DNMT1 (0.47) | DHFRCES1GPR84ALDH1A1HSD17B10 | |
| SCHEMBL367587 | 0.80 | DNMT1 (0.47) | DHFRCES1GPR84ALDH1A1HSD17B10 | |
| SCHEMBL338172 | 0.80 | CES1 (0.55) | DHFRCES1GPR84ALDH1A1HSD17B10 | |
| SCHEMBL7243627 | 0.76 | CES1 (0.52) | DHFRCES1GPR84ALDH1A1HSD17B10 | |
| SCHEMBL27263879 | 0.75 | ALDH1A1 (0.53) | DHFRALDH1A1HSD17B10HIF1ATSHR | |
| SCHEMBL29663473 | 0.75 | GPR84 (0.53) | DHFRCES1GPR84ALDH1A1HSD17B10 | |
| SCHEMBL28620398 | 0.73 | CES1 (0.49) | DHFRCES1GPR84ALDH1A1HSD17B10 | |
| Biphenyl SCHEMBL28230506 | 0.73 | CES1 (0.49) | CES1GPR84ALDH1A1HSD17B10HIF1A | |
| SCHEMBL29858479 | 0.73 | KDM4E (0.42) | DHFRGPR84ALDH1A1HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0433424-B1 | IMPROVED ASYMMETRIC CATALYTIC HYDROGENATION OF ALPHA-ARYLPROPENOIC ACIDS | MONSANTO CO (US) | 1995-05-24 | — | — | EP | claimed |
| CN-115124460-A | Dinaphthalene axis chiral ligand containing coordination unit and preparation method and application thereof | 华东理工大学 | 2022-09-30 | — | — | CN | disclosed |
| EP-2560959-B1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2014-08-20 | — | — | EP | disclosed |
| EP-2560960-B1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2014-02-26 | — | — | EP | disclosed |
| US-8524915-B2 | Process for the preparation of pyrazole carboxylic acid amides | SYNGENTA CROP PROTECTION LLC (US) | 2013-09-03 | — | — | US | disclosed |
| US-8519152-B2 | Process for the preparation of pyrazole carboxylic acid amides | SYNGENTA CROP PROTECTION LLC (US) | 2013-08-27 | — | — | US | disclosed |
| US-8519151-B2 | Process for the preparation of pyrazole carboxylic acid amides | SYNGENTA CROP PROTECTION LLC (US) | 2013-08-27 | — | — | US | disclosed |
| EP-2316813-B1 | Process for the preparation of amines | SYNGENTA PARTICIPATIONS AG (CH) | 2013-04-03 | — | — | EP | disclosed |
| EP-2560958-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | Syngenta Participations AG (CH) | 2013-02-27 | — | — | EP | disclosed |
| EP-2560959-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | Syngenta Participations AG (CH) | 2013-02-27 | — | — | EP | disclosed |
| WO-2011131546-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011131545-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-10-27 | — | — | WO | disclosed |
| EP-2316813-A1 | Process for the preparation of amines | Syngenta Participations AG (CH) | 2011-05-04 | — | — | EP | disclosed |
| EP-2316814-A1 | Process for preparation of halogen substituted benzonorbornenes derivatives | Syngenta Participations AG (CH) | 2011-05-04 | — | — | EP | disclosed |
| EP-2316809-A1 | Process for the preparation of benzonorbornane derivatives | Syngenta Participations AG (CH) | 2011-05-04 | — | — | EP | disclosed |
| EP-2316815-A1 | Process for preparation of halogen substituted arynes | Syngenta Participations AG (CH) | 2011-05-04 | — | — | EP | disclosed |
| US-7781615-B2 | Process for the preparation of amines | SYNGENTA CROP PROTECTION, INC. (US) | 2010-08-24 | — | — | US | disclosed |
| US-20090221856-A1 | PROCESS FOR THE PREPARATION OF AMINES | SYNGENTA CROP PROTECTION, INC. (US) | 2009-09-03 | — | — | US | disclosed |
| EP-1963251-A2 | PROCESS FOR THE PREPARATION OF AMINES | Syngeta Participations AG (CH) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007068417-A2 | PROCESS FOR THE PREPARATION OF AMINES | SYNGENTA PARTICIPATIONS AG (CH) | 2007-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221856-A1 | PROCESS FOR THE PREPARATION OF AMINES | HRH3, PAH, C1R | DHFR 221/4885CES1 564/4885GPR84 3821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.