Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 2/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 3/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18204036 | 1.00 | ALDH1A1 (0.41) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL27691293 | 0.87 | TRPM8 (0.41) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL27691292 | 0.87 | TRPM8 (0.41) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL1493571 | 0.84 | CACNA1B (0.38) | LMNAHSD17B10MEN1KMT2AOPRK1 | |
| SCHEMBL1493572 | 0.84 | CACNA1B (0.38) | LMNAHSD17B10MEN1KMT2AOPRK1 | |
| SCHEMBL4564174 | 0.83 | MDM2 (0.39) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL4564346 | 0.83 | ALDH1A1 (0.42) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL4564347 | 0.83 | ALDH1A1 (0.42) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL3143341 | 0.81 | MEN1 (0.42) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL628088 | 0.80 | NR1H2 (0.44) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013175-B9 | p38 MAP KINASE INHIBITORS | MACROPHAGE PHARMA LTD (GB) | 2020-11-11 | — | — | EP | disclosed |
| EP-2013175-B1 | p38 MAP KINASE INHIBITORS | CHROMA THERAPEUTICS LTD (GB) | 2016-11-09 | — | — | EP | disclosed |
| CN-102942520-B | P38 map kinase inhibitors | CHROMA THERAPEUTICS LTD | 2015-03-04 | — | — | CN | disclosed |
| CN-101437799-A | P38MAP kinase inhibitors | CHROMA THERAPEUTICS LTD (GB) | 2009-05-20 | — | — | CN | disclosed |