Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 2/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18203893 | 0.84 | SLC7A5 (0.38) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 | |
| SCHEMBL12234610 | 0.84 | MAPK14 (0.41) | MDM2MAPK14 | |
| SCHEMBL18204036 | 0.83 | ALDH1A1 (0.41) | MDM2ALDH1A1LMNAPOLBHSD17B10 | |
| SCHEMBL18204035 | 0.83 | ALDH1A1 (0.41) | MDM2ALDH1A1LMNAPOLBHSD17B10 | |
| SCHEMBL27691292 | 0.83 | TRPM8 (0.41) | MDM2TRPM8ALDH1A1LMNAPOLB | |
| SCHEMBL27691293 | 0.83 | TRPM8 (0.41) | MDM2TRPM8ALDH1A1LMNAPOLB | |
| SCHEMBL18203963 | 0.80 | AAK1 (0.44) | MAPK14SLC7A5 | |
| SCHEMBL18203964 | 0.80 | AAK1 (0.44) | MAPK14SLC7A5 | |
| SCHEMBL18204129 | 0.77 | MAPK14 (0.34) | MDM2MAPK14ALDH1A1L3MBTL1BACE1 | |
| SCHEMBL628088 | 0.76 | NR1H2 (0.44) | ALDH1A1LMNAPOLBHSD17B10L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013175-A1 | p38 MAP KINASE INHIBITORS | Chroma Therapeutics Limited (GB) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007129040-A1 | p38 MAP KINASE INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2007-11-15 | — | — | WO | disclosed |