Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.58 |
| ▸ | HSD17B3 | P37058 | 3/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SHBG | P04278 | 2/20 | 0.40 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.40 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16010063 | 0.83 | CYP19A1 (0.59) | CYP19A1GPBAR1CYP3A4MEN1KMT2A | |
| SCHEMBL16020098 | 0.83 | GPBAR1 (0.44) | CYP19A1HSD17B3GPBAR1LMNACYP3A4 | |
| SCHEMBL16010607 | 0.82 | GPBAR1 (0.62) | HSD17B3GPBAR1LMNACYP3A4MEN1 | |
| SCHEMBL16009556 | 0.75 | HSD17B3 (0.45) | HSD17B3GPBAR1LMNACYP3A4MEN1 | |
| SCHEMBL1650324 | 0.73 | CYP19A1 (1.00) | CYP19A1HSD17B3GPBAR1LMNACYP3A4 | |
| SCHEMBL1908291 | 0.73 | CYP19A1 (1.00) | CYP19A1HSD17B3GPBAR1LMNACYP3A4 | |
| SCHEMBL17817126 | 0.73 | CYP19A1 (1.00) | CYP19A1HSD17B3GPBAR1LMNACYP3A4 | |
| SCHEMBL20714758 | 0.73 | CYP19A1 (1.00) | CYP19A1HSD17B3GPBAR1LMNACYP3A4 | |
| SCHEMBL12825203 | 0.73 | CYP19A1 (1.00) | CYP19A1HSD17B3GPBAR1LMNACYP3A4 | |
| SCHEMBL17341027 | 0.73 | CYP19A1 (1.00) | CYP19A1HSD17B3GPBAR1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160326127-A1 | NEUROACTIVE SUBSTITUTED CYCLOPENTA[b]PHENANTHRENES AS MODULATORS FOR GABA TYPE-A RECEPTORS | WASHINGTON UNIVERSITY | 2016-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160326127-A1 | NEUROACTIVE SUBSTITUTED CYCLOPENTA[b]PHENANTHRENES AS MODULATORS FOR GABA TYPE-A RECEPTORS | GABRB3, GABRB1, GABRB2 | CYP19A1 796/4885HSD17B3 533/4885GPBAR1 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.