Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.40 |
| ▸ | GRM6 | O15303 | 2/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.38 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.37 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | RBP4 | P02753 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28379880 | 0.86 | GRIN2B (0.56) | GRIN1GRIN2BFKBP1AGRM6GRM2 | |
| SCHEMBL28379878 | 0.86 | GRIN2B (0.56) | GRIN1GRIN2BFKBP1AGRM6GRM2 | |
| SCHEMBL26966767 | 0.85 | GRIN2B (0.45) | GRIN1GRIN2BKMT2A | |
| SCHEMBL2418001 | 0.84 | RIPK1 (0.48) | GRIN1GRIN2BKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL16422920 | 0.84 | GRIN2B (0.45) | GRIN1GRIN2BSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL18035794 | 0.83 | ALDH1A1 (0.41) | GRIN1GRIN2BCARM1PRMT6SMN1; SMN2 | |
| SCHEMBL3125608 | 0.81 | CARM1 (0.49) | GRIN1GRIN2BFKBP1AKMT2ACARM1 | |
| SCHEMBL15212446 | 0.79 | RORC (0.50) | — | |
| SCHEMBL322113 | 0.77 | TSHR (0.43) | GRIN2BKMT2AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL321919 | 0.77 | HPGD (0.54) | KMT2AMEN1SMN1; SMN2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9493481-B2 | Substituted 5-aminothieno[2,3—C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2016-11-15 | — | — | US | disclosed |