Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 2/20 | 0.44 |
| ▸ | EDNRA | P25101 | 2/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.35 |
| ▸ | S100A4 | P26447 | 1/20 | 0.34 |
| ▸ | PTPRC | P08575 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18209302 | 1.00 | EDNRB (0.44) | EDNRBEDNRABCL2MCL1CYP1A2 | |
| SCHEMBL18209300 | 0.85 | EDNRB (0.42) | EDNRBEDNRABCL2MCL1CYP1A2 | |
| SCHEMBL18215457 | 0.83 | TDP2 (0.38) | EDNRBEDNRABCL2MCL1CYP1A2 | |
| SCHEMBL18209326 | 0.83 | TDP2 (0.38) | EDNRBEDNRABCL2MCL1CYP1A2 | |
| SCHEMBL23784644 | 0.82 | TGM2 (0.36) | TGM2CES1TDP2TP53MDM2 | |
| SCHEMBL18209303 | 0.78 | HSD17B10 (0.51) | EDNRBEDNRACYP1A2PARP1 | |
| SCHEMBL18215417 | 0.78 | HSD17B10 (0.51) | EDNRBEDNRACYP1A2PARP1 | |
| SCHEMBL18209306 | 0.76 | HSD17B10 (0.47) | EDNRBEDNRACYP1A2MAPK1TGM2 | |
| SCHEMBL18215447 | 0.76 | HSD17B10 (0.47) | EDNRBEDNRACYP1A2MAPK1TGM2 | |
| SCHEMBL23784662 | 0.72 | TDP2 (0.35) | EDNRBEDNRABCL2HSP90AA1NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3292102-B1 | ISOINDOLINONES, PROCESSES FOR THE PRODUCTION OF CHIRAL DERIVATIVES THEREOF AND USE THEREOF | UNIV DEGLI STUDI DI SALERNO (IT) | 2021-09-08 | — | — | EP | disclosed |
| WO-2016178140-A1 | ISOINDOLINONES, PROCESSES FOR THE PRODUCTION OF CHIRAL DERIVATIVES THEREOF AND USE THEREOF | UNIVERSITA' DEGLI STUDI DI SALERNO (IT) | 2016-11-10 | — | — | WO | disclosed |