Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 14/20 | 0.57 |
| ▸ | ATF1 | P18846 | 13/20 | 0.57 |
| ▸ | XPO1 | O14980 | 4/20 | 0.54 |
| ▸ | JUN | P05412 | 2/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.53 |
| ▸ | RELA | Q04206 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7489466 | 0.86 | NFKB1 (0.59) | NFKB1ATF1XPO1JUNNFKB2 | |
| SCHEMBL2307377 | 0.83 | NFKB1 (0.61) | NFKB1ATF1XPO1JUNNFKB2 | |
| SCHEMBL6977551 | 0.80 | NFKB1 (0.62) | NFKB1ATF1XPO1JUNNFKB2 | |
| SCHEMBL1822766 | 0.77 | ATF1 (0.46) | NFKB1ATF1LMNASCD | |
| SCHEMBL4745582 | 0.75 | CNR2 (0.69) | NFKB1ATF1XPO1LMNA | |
| SCHEMBL3379524 | 0.74 | CNR2 (0.64) | NFKB1ATF1XPO1 | |
| SCHEMBL3380681 | 0.74 | CNR2 (0.64) | NFKB1ATF1XPO1 | |
| SCHEMBL6288528 | 0.74 | ATF1 (0.68) | NFKB1ATF1XPO1JUNNFKB2 | |
| SCHEMBL8518174 | 0.73 | NFKB1 (0.62) | NFKB1ATF1XPO1JUNNFKB2 | |
| SCHEMBL3378920 | 0.73 | CNR2 (0.64) | NFKB1ATF1XPO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8030488-B2 | Piperazine derivatives as stearoyl-coa desaturase inhibitors and their use as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2011-10-04 | — | — | US | disclosed |
| EP-2316828-A1 | Piperazine derivatives and their use as therapeutic agents | Xenon Pharmaceuticals Inc. (CA) | 2011-05-04 | — | — | EP | disclosed |