Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 17/20 | 0.62 |
| ▸ | ATF1 | P18846 | 16/20 | 0.62 |
| ▸ | XPO1 | O14980 | 4/20 | 0.60 |
| ▸ | JUN | P05412 | 2/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.59 |
| ▸ | RELA | Q04206 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL473934 | 0.81 | ATF1 (0.62) | NFKB1ATF1XPO1JUNNFKB2 | |
| SCHEMBL6643357 | 0.80 | NFKB1 (0.49) | NFKB1ATF1XPO1JUNNFKB2 | |
| SCHEMBL1821585 | 0.80 | NFKB1 (0.57) | NFKB1ATF1XPO1JUNNFKB2 | |
| SCHEMBL2307377 | 0.80 | NFKB1 (0.61) | NFKB1ATF1XPO1JUNNFKB2 | |
| SCHEMBL8518174 | 0.79 | NFKB1 (0.62) | NFKB1ATF1XPO1JUNNFKB2 | |
| SCHEMBL7489466 | 0.78 | NFKB1 (0.59) | NFKB1ATF1XPO1JUNNFKB2 | |
| SCHEMBL480176 | 0.77 | XPO1 (0.62) | NFKB1ATF1XPO1JUNNFKB2 | |
| SCHEMBL79014 | 0.77 | NFKB1 (0.60) | NFKB1ATF1XPO1JUNNFKB2 | |
| SCHEMBL8398500 | 0.75 | NFKB1 (0.53) | NFKB1ATF1XPO1JUNNFKB2 | |
| SCHEMBL9564861 | 0.75 | NFKB1 (0.58) | NFKB1ATF1XPO1JUNNFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242396-B1 | NEW P2X 7 RECEPTOR ANTAGONISTS FOR USE IN THE TREATMENT OF INFLAMMATORY, IMMUNE OR CARDIOVASCULAR DISEASES | ASTRAZENECA AB (SE) | 2003-09-24 | — | — | EP | disclosed |
| EP-1242396-A1 | NEW P2X 7 RECEPTOR ANTAGONISTS FOR USE IN THE TREATMENT OF INFLAMMATORY, IMMUNE OR CARDIOVASCULAR DISEASES | AstraZeneca AB (SE) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001044213-A1 | NEW P2X7 RECEPTOR ANTAGONISTS FOR USE IN THE TREATMENT OF INFLAMMATORY, IMMUNE OR CARDIOVASCULAR DISEASES | ASTRAZENECA AB (SE) | 2001-06-21 | — | — | WO | disclosed |