Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11981772 | 0.83 | SRD5A2 (0.41) | ALDH1A1HPGDL3MBTL1RAB9ANPC1 | |
| SCHEMBL12550200 | 0.78 | HTR2B (0.42) | KDM4EALDH1A1RAB9ANPC1CYP1A2 | |
| SCHEMBL8028626 | 0.76 | FGFR1 (0.44) | FGFR1FGFR2FGFR4FGFR3SRC | |
| SCHEMBL13938552 | 0.76 | KMT2A (0.45) | KDM4EALDH1A1HPGDL3MBTL1RAB9A | |
| Fluorene SCHEMBL147376 | 0.72 | HTR2B (0.51) | KDM4EALDH1A1HPGDRAB9ANPC1 | |
| SCHEMBL11099181 | 0.69 | ALDH1A1 (0.52) | FGFR1FGFR2FGFR4FGFR3SRC | |
| SCHEMBL12255634 | 0.69 | ALDH1A1 (0.43) | KDM4EALDH1A1HPGDL3MBTL1RAB9A | |
| SCHEMBL6654078 | 0.69 | ALDH1A1 (0.52) | FGFR1FGFR2FGFR4FGFR3SRC | |
| SCHEMBL12255635 | 0.69 | CYP1A2 (0.40) | KDM4EALDH1A1HPGDL3MBTL1RAB9A | |
| Fluorene SCHEMBL2708609 | 0.68 | TSHR (0.68) | KDM4EALDH1A1HPGDL3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8471010-B2 | Synthesis of dihydrothieno[3,2-d]pyrimidine diols | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-06-25 | — | — | US | disclosed |
| US-8471010-B2 | Synthesis of dihydrothieno[3,2-d]pyrimidine diols | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-06-25 | — | — | US | disclosed |
| EP-2315755-B1 | SYNTHESIS OF DIHYDROTHIENO[3,2-d]PYRIMIDINE DIOLS AND SIMILAR PYRIMIDINE DIOLS | BOEHRINGER INGELHEIM INT (DE) | 2012-08-08 | — | — | EP | disclosed |
| US-20110130563-A1 | SYNTHESIS IF DIHYDROTHIENO[3,2-D]PYRIMIDINE DIOLS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-06-02 | — | — | US | disclosed |
| US-20110130563-A1 | SYNTHESIS IF DIHYDROTHIENO[3,2-D]PYRIMIDINE DIOLS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-06-02 | — | — | US | disclosed |
| EP-2315755-A2 | SYNTHESIS OF DIHYDROTHIENO[3,2-d]PYRIMIDINE DIOLS AND SIMILAR PYRIMIDINE DIOLS | Boehringer Ingelheim International GmbH (DE) | 2011-05-04 | — | — | EP | disclosed |
| WO-2009140127-A2 | SYNTHESIS OF DIHYDROTHIENO[3,2-d]PYRIMIDINE DIOLS AND SIMILAR PYRIMIDINE DIOLS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-11-19 | — | — | WO | disclosed |
| WO-2009140127-A2 | SYNTHESIS OF DIHYDROTHIENO[3,2-d]PYRIMIDINE DIOLS AND SIMILAR PYRIMIDINE DIOLS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130563-A1 | SYNTHESIS IF DIHYDROTHIENO[3,2-D]PYRIMIDINE DIOLS | DPYD, DHODH, PDE4B | FGFR1 2459/4885FGFR2 2497/4885FGFR4 630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.