Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA2 | O43464 | 8/20 | 0.35 |
| ▸ | HTRA1 | Q92743 | 8/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | OXTR | P30559 | 1/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.32 |
| ▸ | ALB | P02768 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14932607 | 0.80 | HTRA2 (0.54) | HTRA2HTRA1WDR5FOLH1ALB | |
| SCHEMBL13833492 | 0.78 | HTRA2 (0.38) | HTRA2HTRA1WDR5FOLH1ALB | |
| SCHEMBL18220762 | 0.76 | CA12 (0.44) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL10315740 | 0.75 | CA12 (0.50) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL11983772 | 0.75 | CA12 (0.50) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL20047392 | 0.74 | FOLH1 (0.51) | HTRA2HTRA1WDR5FOLH1ALB | |
| SCHEMBL14932614 | 0.74 | HTRA2 (0.52) | HTRA2HTRA1WDR5FOLH1ALB | |
| SCHEMBL18220760 | 0.74 | CA1 (0.47) | KDM4EMEN1ALDH1A1HPGDKMT2A | |
| SCHEMBL20235710 | 0.74 | HTRA2 (0.49) | HTRA2HTRA1WDR5FOLH1ALB | |
| SCHEMBL13833496 | 0.72 | HTRA2 (0.37) | HTRA2HTRA1WDR5FOLH1ALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016179398-A1 | ISOFORM-SELECTIVE LYSINE DEACETYLASE INHIBITORS | WASHINGTON UNIVERSITY (US) | 2016-11-10 | — | — | WO | disclosed |