Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 1/20 | 0.56 |
| ▸ | ABAT | P80404 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | LOXL2 | Q9Y4K0 | 7/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
| ▸ | NOS2 | P35228 | 2/20 | 0.41 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyl Alcohol SCHEMBL22528993 | 0.80 | ABAT (0.67) | F11ABATHRH3LOXL2F10 | |
| SCHEMBL19692606 | 0.79 | ALDH1A1 (0.50) | F11LOXL2CA6CA14 | |
| SCHEMBL15828 | 0.76 | HRH3 (0.79) | F11ABATHRH3LOXL2F10 | |
| SCHEMBL27238704 | 0.76 | HRH3 (0.79) | F11ABATHRH3LOXL2F10 | |
| SCHEMBL15740559 | 0.76 | ESR1 (0.52) | ABATTAAR1ENPP2CA12CA1 | |
| SCHEMBL1358563 | 0.74 | IDO1 (0.46) | TAAR1ENPP2 | |
| SCHEMBL22010359 | 0.74 | CYP3A4 (0.41) | — | |
| SCHEMBL15106880 | 0.74 | CA1 (0.46) | TAAR1CA1CA2 | |
| SCHEMBL3568612 | 0.74 | IDO1 (0.46) | LOXL2TAAR1 | |
| SCHEMBL1356833 | 0.74 | IDO1 (0.46) | TAAR1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170226155-A1 | Smart Pro-Drugs of Serine Protease Inhibitors | TRUSTEES OF TUFTS COLLEGE (US) | 2017-08-10 | — | — | US | disclosed |
| US-9629921-B2 | Smart pro-drugs of serine protease inhibitors | TRUSTEES OF TUFTS COLLEGE (US) | 2017-04-25 | — | — | US | disclosed |
| US-20130303435-A1 | Smart Pro-Drugs of Serine Protease Inhibitors | BACH BIOSCIENCES, LLC | 2013-11-14 | — | — | US | disclosed |
| EP-2319523-A1 | Serine protease inhibitors | Trustees Of Tufts College (US) | 2011-05-11 | — | — | EP | disclosed |
| EP-2204181-A2 | Protease inhibitors | Trustees of Tufts College (US) | 2010-07-07 | — | — | EP | disclosed |
| US-20100168032-A1 | Smart Pro-Drugs of Serine Protease Inhibitors | TRUSTEES OF TUFTS COLLEGE (US) | 2010-07-01 | — | — | US | disclosed |
| US-7691967-B2 | Smart pro-drugs of serine protease inhibitors | TRUSTEES OF TUFTS COLLEGE (US) | 2010-04-06 | — | — | US | disclosed |
| US-20060089312-A1 | Protease inhibitors | BACH BIOSCIENCES, LLC | 2006-04-27 | — | — | US | disclosed |
| EP-1499336-A4 | PROTEASE INHIBITORS | TUFTS COLLEGE (US) | 2005-06-01 | — | — | EP | disclosed |
| EP-1499336-A2 | PROTEASE INHIBITORS | Trustees of Tufts College (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003092605-A9 | PROTEASE INHIBITORS | TUFTS COLLEGE (US) | 2004-04-08 | — | — | WO | disclosed |
| WO-2003092605-A2 | PROTEASE INHIBITORS | TRUSTEES OF TUFTS COLLEGE (US) | 2003-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130303435-A1 | Smart Pro-Drugs of Serine Protease Inhibitors | FAP, PREP, CTSC | F11 954/4885ABAT 2677/4885HRH3 4306/4885 |
| US-20170226155-A1 | Smart Pro-Drugs of Serine Protease Inhibitors | FAP, PREP, CTSC | F11 954/4885ABAT 2677/4885HRH3 4306/4885 |
| US-20060089312-A1 | Protease inhibitors | FAP, PREP, TFPI | F11 873/4885ABAT 2795/4885HRH3 4406/4885 |
| US-20100168032-A1 | Smart Pro-Drugs of Serine Protease Inhibitors | FAP, PREP, CTSC | F11 954/4885ABAT 2677/4885HRH3 4306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.