Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.83 |
| ▸ | NOS2 | P35228 | 7/20 | 0.53 |
| ▸ | NOS1 | P29475 | 5/20 | 0.53 |
| ▸ | NOS3 | P29474 | 4/20 | 0.53 |
| ▸ | ARG2 | P78540 | 4/20 | 0.52 |
| ▸ | ARG1 | P05089 | 3/20 | 0.52 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL1822760 | 1.00 | GSR (0.83) | GSRNOS2NOS1NOS3ARG2 | |
| Ornithine Aketoglutarate SCHEMBL27565629 | 0.94 | GSR (0.72) | GSRNOS2NOS1NOS3ARG2 | |
| D-Ornithine SCHEMBL27565626 | 0.94 | GSR (0.72) | GSRNOS2NOS1NOS3ARG2 | |
| Lysine SCHEMBL18396695 | 0.91 | GSR (0.91) | GSRNOS2NOS1NOS3ARG2 | |
| Lysine SCHEMBL28080783 | 0.91 | GSR (0.91) | GSRNOS2NOS1NOS3ARG2 | |
| Lysine SCHEMBL31541159 | 0.91 | GSR (0.91) | GSRNOS2NOS1NOS3ARG2 | |
| Lysine SCHEMBL18396696 | 0.91 | GSR (0.91) | GSRNOS2NOS1NOS3ARG2 | |
| Lysine SCHEMBL456381 | 0.91 | GSR (1.00) | GSRNOS2NOS1NOS3ARG2 | |
| Lysine SCHEMBL15303774 | 0.91 | GSR (1.00) | GSRNOS2NOS1NOS3ARG2 | |
| Lysine SCHEMBL1000151 | 0.91 | GSR (1.00) | GSRNOS2NOS1NOS3ARG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023164003-A2 | REAGENTS FOR LABELING BIOMOLECULES AND USES THEREOF | ULTIMA GENOMICS, INC. (US) | 2023-08-31 | — | — | WO | disclosed |
| US-11369586-B2 | Antifungal peptoids | Middle Tennessee State University (US) | 2022-06-28 | — | — | US | disclosed |
| US-20210231677-A1 | TRACELESS IMMOBILIZATION OF ANALYTES FOR SAMDI MASS SPECTROMETRY | NORTHWESTERN UNIVERSITY | 2021-07-29 | — | — | US | disclosed |
| US-20200188354-A1 | ANTIFUNGAL PEPTOIDS | Middle Tennessee State University | 2020-06-18 | — | — | US | disclosed |
| WO-2019237019-A9 | TRACELESS IMMOBILIZATION OF ANALYTES FOR SAMDI MASS SPECTROMETRY | NORTHWESTERN UNIVERSITY (US) | 2020-06-11 | — | — | WO | disclosed |
| US-9050378-B2 | N2S2 chelate-targeting ligand conjugates | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-06-09 | — | — | US | disclosed |
| EP-2316493-A2 | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging | Board of Regents, The University of Texas System (US) | 2011-05-04 | — | — | EP | disclosed |
| EP-1562641-A4 | ETHYLENEDICYSTEINE (EC)-DRUG CONJUGATES, COMPOSITIONS AND METHODS FOR TISSUE SPECIFIC DISEASE IMAGING | UNIV TEXAS (US) | 2008-12-03 | — | — | EP | disclosed |
| EP-1562641-A2 | ETHYLENEDICYSTEINE (EC)-DRUG CONJUGATES, COMPOSITIONS AND METHODS FOR TISSUE SPECIFIC DISEASE IMAGING | BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM (US) | 2005-08-17 | — | — | EP | disclosed |
| US-20050129619-A1 | N2S2 chelate-targeting ligand conjugates | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2005-06-16 | — | — | US | disclosed |
| US-20040166058-A1 | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2004-08-26 | — | — | US | disclosed |
| WO-2004044227-A2 | ETHYLENEDICYSTEINE (EC)-DRUG CONJUGATES, COMPOSITIONS AND METHODS FOR TISSUE SPECIFIC DISEASE IMAGING | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2004-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040166058-A1 | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging | TEK, TIE1, CD40 | GSR 2261/4885NOS2 1321/4885NOS1 2917/4885 |
| US-20050129619-A1 | N2S2 chelate-targeting ligand conjugates | TYMS, CCNT2, TEK | GSR 3954/4885NOS2 573/4885NOS1 1576/4885 |
| US-11369586-B2 | Antifungal peptoids | ERG28, DPM1, QPCTL | GSR 1940/4885NOS2 1959/4885NOS1 2154/4885 |
| US-20200188354-A1 | ANTIFUNGAL PEPTOIDS | ERG28, DPM1, QPCTL | GSR 1940/4885NOS2 1959/4885NOS1 2154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.