Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CCR1 | P32246 | 2/20 | 0.45 |
| ▸ | CCR5 | P51681 | 2/20 | 0.45 |
| ▸ | CCR8 | P51685 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | METAP1 | P53582 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.45 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650294 | 0.71 | KDM4E (0.51) | TGFBR1KDM4ENPC1MAPTRAB9A | |
| SCHEMBL323086 | 0.71 | KDM4E (0.68) | KDM4ENPC1MAPTRAB9AGLA | |
| SCHEMBL6743757 | 0.70 | KDM4E (0.60) | KDM4ENPC1MAPTRAB9AGLA | |
| Dipyridyl SCHEMBL2386179 | 0.68 | KDM4E (0.93) | KDM4ENPC1MAPTRAB9AGLA | |
| Dipyridyl SCHEMBL8514685 | 0.68 | KDM4E (0.93) | KDM4ENPC1MAPTRAB9AGLA | |
| Dipyridyl SCHEMBL31663992 | 0.68 | KDM4E (0.93) | KDM4ENPC1MAPTRAB9AGLA | |
| SCHEMBL21495007 | 0.68 | TGFBR1 (0.63) | TGFBR1MAPTCYP1A2 | |
| SCHEMBL4614666 | 0.67 | KDM4E (0.54) | KDM4ENPC1MAPTRAB9AGLA | |
| SCHEMBL6744657 | 0.67 | KDM4E (0.56) | KDM4ENPC1MAPTRAB9AGLA | |
| SCHEMBL176039 | 0.67 | KDM4E (0.68) | KDM4ENPC1MAPTRAB9AGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016183173-A1 | ANTIPARASITIC COMPOUNDS | Avista Pharma Solutions (US) | 2016-11-17 | — | — | WO | disclosed |