Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.57 |
| ▸ | MTNR1A | P48039 | 14/20 | 0.56 |
| ▸ | MTNR1B | P49286 | 14/20 | 0.56 |
| ▸ | NQO2 | P16083 | 4/20 | 0.56 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.54 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18239786 | 0.90 | HTR6 (0.56) | HTR6MTNR1AMTNR1BNQO2PTGDR2 | |
| SCHEMBL18222517 | 0.90 | HTR6 (0.56) | HTR6MTNR1AMTNR1BPTGDR2PTGDR | |
| SCHEMBL18239688 | 0.88 | HTR6 (0.45) | HTR6MTNR1AMTNR1BNQO2PTGDR2 | |
| SCHEMBL18239789 | 0.88 | PTGDR2 (0.46) | HTR6MTNR1AMTNR1BNQO2PTGDR2 | |
| SCHEMBL18222515 | 0.88 | PTGDR2 (0.48) | HTR6MTNR1AMTNR1BNQO2PTGDR2 | |
| SCHEMBL18222559 | 0.87 | PTGDR2 (0.53) | HTR6MTNR1AMTNR1BNQO2PTGDR2 | |
| SCHEMBL18239831 | 0.85 | MAPT (0.44) | HTR6MTNR1AMTNR1BNQO2PTGDR2 | |
| SCHEMBL18239857 | 0.85 | PTGDR2 (0.44) | HTR6MTNR1AMTNR1BNQO2PTGDR2 | |
| SCHEMBL18239687 | 0.84 | PTGDR2 (0.45) | HTR6MTNR1AMTNR1BNQO2PTGDR2 | |
| SCHEMBL18239765 | 0.83 | PTGDR2 (0.48) | HTR6MTNR1AMTNR1BNQO2PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9637451-B2 | Indole compound | ASTELLAS PHARMA INC. (JP) | 2017-05-02 | — | — | US | disclosed |
| EP-3095781-A1 | INDOLE COMPOUND | Astellas Pharma Inc. (JP) | 2016-11-23 | — | — | EP | disclosed |
| US-20160332966-A1 | INDOLE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2016-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160332966-A1 | INDOLE COMPOUND | MTNR1A, MTNR1B, IDO2 | HTR6 129/4885MTNR1A 1/4885MTNR1B 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.