Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12428840 | 0.89 | MAPT (0.41) | MAPTALDH1A1RXFP1NR3C2PDE3B | |
| SCHEMBL12428824 | 0.87 | NR3C2 (0.43) | MAPTALDH1A1RXFP1NR3C2PDE3B | |
| SCHEMBL18239918 | 0.83 | MAPT (0.37) | MAPTALDH1A1RXFP1NR3C2PDE3B | |
| SCHEMBL561100 | 0.81 | MAOA (0.46) | MAPTALDH1A1ADRB2ADRB1SMN1; SMN2 | |
| SCHEMBL30223645 | 0.81 | MAOA (0.46) | MAPTALDH1A1ADRB2ADRB1SMN1; SMN2 | |
| SCHEMBL17484547 | 0.76 | ADRB2 (0.39) | MAPTALDH1A1RXFP1ADRB2ADRB1 | |
| SCHEMBL12428821 | 0.76 | ADRB2 (0.48) | ADRB2ADRB1HTR2AHTR1ASLC6A4 | |
| SCHEMBL12648407 | 0.75 | DRD2 (0.40) | MAPTRXFP1NR3C2PDE3BPDE3A | |
| SCHEMBL20285626 | 0.72 | NR3C2 (0.38) | MAPTALDH1A1RXFP1NR3C2PDE3B | |
| SCHEMBL17476304 | 0.71 | SMYD3 (0.56) | MAPTALDH1A1DRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016180349-A1 | BIPHENYL DERIVATIVE HAVING BETA2 RECEPTOR EXCITEMENT AND M RECEPTOR ANTAGONISTIC ACTIVITIES AND APPLICATION THEREFOF IN MEDICAMENT | 四川海思科制药有限公司 | 2016-11-17 | — | — | WO | disclosed |