SCHEMBL18247349

SCHEMBL18247349

COc1ccc(CC(C)(Cc2ccc(OC)cc2)S(N)(=O)=O)cc1

nearest known ligand 0.54

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CA1 P00915 6/20 0.54
CA2 P00918 6/20 0.54
CA9 Q16790 5/20 0.54
CA12 O43570 3/20 0.54
CA5A P35218 1/20 0.54
CA14 Q9ULX7 1/20 0.54
HTT P42858 1/20 0.46
APLNR P35414 1/20 0.46
CA4 P22748 2/20 0.45
POLB P06746 1/20 0.45
CA7 P43166 1/20 0.45
ALDH1A1 P00352 2/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
IDO1 P14902 2/20 0.44
AGXT P21549 2/20 0.44
TAAR1 Q96RJ0 1/20 0.44
MMP1 P03956 1/20 0.44
MMP13 P45452 1/20 0.44
PTPRB P23467 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28458665 0.86 CA1 (0.54) CA1CA2CA9CA12CA5A
SCHEMBL28432291 0.78 KMT2A (0.52) CA1CA2CA9CA12CA5A
Sulfuric Acid SCHEMBL28679089 0.77 PTPRB (0.49) CA1CA2CA9CA12CA5A
SCHEMBL19285464 0.77 CA1 (0.49) CA1CA2CA9CA12CA5A
SCHEMBL183751 0.75 SLC6A2 (0.57) CA1CA2CA9CA12CA14
SCHEMBL6541466 0.75 PKM (0.61) CA1CA2CA9CA12CA4
SCHEMBL73472 0.74 IDO1 (0.54) CA1CA2CA9CA12CA14
SCHEMBL754797 0.74 APLNR (0.49) CA1CA2CA9CA12CA5A
SCHEMBL8519536 0.74 IDO1 (0.45) CA1CA2CA9CA12CA14
SCHEMBL19327124 0.74 APLNR (0.49) CA1CA2CA9CA12CA5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3541802-A1 ALKYL SUBSTITUTED TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR Amgen Inc. (US) 2019-09-25 EP disclosed
EP-3541805-A1 HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS Amgen Inc. (US) 2019-09-25 EP disclosed
EP-3541810-A1 TRIAZOLE PHENYL COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR Amgen Inc. (US) 2019-09-25 EP disclosed
EP-3541804-A1 CYCLOALKYL SUBSTITUTED TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR Amgen Inc. (US) 2019-09-25 EP disclosed
EP-3541803-A1 TRIAZOLE PYRIDYL COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR Amgen Inc. (US) 2019-09-25 EP disclosed
EP-3541792-A1 TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR Amgen Inc. (US) 2019-09-25 EP disclosed
EP-3452466-A1 HETEROCYCLIC TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR Amgen Inc. (US) 2019-03-13 EP disclosed
WO-2018097945-A1 HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS AMGEN INC. (US) 2018-05-31 WO disclosed
WO-2018097944-A1 TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR AMGEN INC. (US) 2018-05-31 WO disclosed
WO-2018093577-A1 CYCLOALKYL SUBSTITUTED TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR AMGEN INC. (US) 2018-05-24 WO disclosed
WO-2018093580-A1 TRIAZOLE PYRIDYL COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR AMGEN INC. (US) 2018-05-24 WO disclosed
WO-2018093576-A1 ALKYL SUBSTITUTED TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR AMGEN INC. (US) 2018-05-24 WO disclosed
WO-2018093579-A1 TRIAZOLE PHENYL COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR AMGEN INC. (US) 2018-05-24 WO disclosed
EP-3300500-A1 TRIAZOLE AGONISTS OF THE APJ RECEPTOR Amgen Inc. (US) 2018-04-04 EP disclosed
WO-2017192485-A1 HETEROCYCLIC TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR AMGEN INC. (US) 2017-11-09 WO disclosed
WO-2016187308-A1 TRIAZOLE AGONISTS OF THE APJ RECEPTOR AMGEN INC. (US) 2016-11-24 WO disclosed