SCHEMBL754797

SCHEMBL754797

COc1ccc(CC(Br)(Br)S(=O)(=O)C(Br)(Br)Cc2ccc(OC)cc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
APLNR P35414 2/20 0.49
HTT P42858 1/20 0.49
MMP1 P03956 3/20 0.46
MMP13 P45452 3/20 0.46
PTPRB P23467 1/20 0.46
IDO1 P14902 1/20 0.45
PKM P14618 1/20 0.45
ALDH1A1 P00352 2/20 0.45
CA12 O43570 2/20 0.45
CA1 P00915 2/20 0.45
CA2 P00918 2/20 0.45
CA9 Q16790 2/20 0.45
CA5A P35218 1/20 0.45
CA14 Q9ULX7 1/20 0.45
SMN1; SMN2 Q16637 2/20 0.44
MMP9 P14780 2/20 0.43
CMA1 P23946 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL754030 0.79 APLNR (0.47) APLNRHTTMMP1MMP13PTPRB
SCHEMBL754036 0.78 KMT2A (0.43) IDO1ALDH1A1CA12CA1CA2
SCHEMBL751764 0.75 PLCG1 (0.41) HTTIDO1CA12CA1CA2
SCHEMBL16424752 0.74 IDO1 (0.56) IDO1ALDH1A1CA12CA1CA2
SCHEMBL18247349 0.74 CA1 (0.54) APLNRHTTMMP1MMP13PTPRB
SCHEMBL28458665 0.74 CA1 (0.54) APLNRHTTMMP1MMP13PTPRB
SCHEMBL751657 0.74 CA1 (0.40) IDO1CA12CA1CA2CA9
Sulfuric Acid SCHEMBL28679089 0.73 PTPRB (0.49) APLNRHTTMMP1MMP13PTPRB
SCHEMBL19327124 0.73 APLNR (0.49) APLNRHTTMMP1MMP13PTPRB
SCHEMBL73472 0.73 IDO1 (0.54) IDO1ALDH1A1CA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2213166-B1 Biocidal compounds containing 2-methylisothiazolin-3-one and a haloalkylsulfone THOR GMBH (DE) 2012-03-21 EP claimed