SCHEMBL18248176

SCHEMBL18248176

O=C(OCc1ccccc1)[C@H](O)Cc1ccc(N2CCOCC2)nc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 2/20 0.47
▸ KMT2A Q03164 2/20 0.47
▸ NPSR1 Q6W5P4 2/20 0.47
▸ AOC3 Q16853 4/20 0.47
▸ TSHR P16473 2/20 0.46
▸ LMNA P02545 1/20 0.46
▸ POLB P06746 1/20 0.46
▸ MAPT P10636 1/20 0.46
▸ CASP1 P29466 1/20 0.46
▸ KDM4E B2RXH2 1/20 0.45
▸ CNR2 P34972 2/20 0.44
▸ CNR1 P21554 1/20 0.44
▸ DGAT1 O75907 1/20 0.44
▸ ALDH1A1 P00352 2/20 0.44
▸ PARP1 P09874 1/20 0.43
▸ ME2 P23368 1/20 0.42
▸ ME1 P48163 1/20 0.42
▸ ME3 Q16798 1/20 0.42
▸ CYP11B2 P19099 2/20 0.42
▸ CYP11B1 P15538 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19245059 0.89 AOC3 (0.50) MEN1KMT2ANPSR1AOC3TSHR
SCHEMBL23279498 0.88 KDM4E (0.47) MEN1KMT2ANPSR1AOC3TSHR
SCHEMBL23279546 0.86 KDM4E (0.45) MEN1KMT2ANPSR1AOC3TSHR
SCHEMBL19088472 0.84 MEN1 (0.53) MEN1KMT2ANPSR1TSHRLMNA
SCHEMBL18256449 0.84 MEN1 (0.53) MEN1KMT2ANPSR1TSHRLMNA
SCHEMBL18248128 0.84 AOC3 (0.54) MEN1KMT2AAOC3LMNAPOLB
SCHEMBL31560871 0.82 MEN1 (0.48) MEN1KMT2ANPSR1AOC3TSHR
SCHEMBL18256436 0.82 MEN1 (0.48) MEN1KMT2ANPSR1AOC3TSHR
SCHEMBL19088554 0.81 AOC3 (0.53) MEN1KMT2ANPSR1AOC3TSHR
SCHEMBL19066710 0.80 MEN1 (0.47) MEN1KMT2ANPSR1AOC3TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12286455-B2 Anthelmintic depsipeptide compounds Boehringer Ingelheim Animal Health USA Inc. (US) 2025-04-29 — — US disclosed
US-12018048-B2 Anthelmintic depsipeptide compounds Boehringer Ingelheim Animal Health USA Inc. (US) 2024-06-25 — — US disclosed
US-12018048-B2 Anthelmintic depsipeptide compounds Boehringer Ingelheim Animal Health USA Inc. (US) 2024-06-25 — — US disclosed
US-12018048-B2 Anthelmintic depsipeptide compounds Boehringer Ingelheim Animal Health USA Inc. (US) 2024-06-25 — — US disclosed
EP-3397638-B1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) 2023-08-23 — — EP disclosed
EP-3397638-B1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) 2023-08-23 — — EP disclosed
CN-114891070-A Anthelmintic depsipeptide compounds 勃林格殷格翰动物保健美国公司 2022-08-12 — — CN disclosed
US-11382949-B2 Anthelmintic depsipeptide compounds Boehringer Ingelheim Animal Health USA Inc. (US) 2022-07-12 — — US disclosed
US-11382949-B2 Anthelmintic depsipeptide compounds Boehringer Ingelheim Animal Health USA Inc. (US) 2022-07-12 — — US disclosed
CN-107835818-B Anthelmintic depsipeptide compounds 勃林格殷格翰动物保健美国公司 2022-04-29 — — CN disclosed
US-10081656-B2 Anthelmintic depsipeptide compounds MERIAL, INC. (US) 2018-09-25 — — US disclosed
WO-2018093920-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS MERIAL, INC. (US) 2018-05-24 — — WO disclosed
EP-3298027-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS Merial, Inc. (US) 2018-03-28 — — EP disclosed
US-20170233438-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS MERIAL INC. (US) 2017-08-17 — — US disclosed
US-20170233438-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS MERIAL INC. (US) 2017-08-17 — — US disclosed
WO-2017116702-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS MERIAL, INC. (US) 2017-07-06 — — WO disclosed
US-20170022253-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS MERIAL INC. (US) 2017-01-26 — — US disclosed
US-20170022253-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS MERIAL INC. (US) 2017-01-26 — — US disclosed
WO-2016187534-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS MERIAL, INC. (US) 2016-11-24 — — WO disclosed
WO-2016187534-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS MERIAL, INC. (US) 2016-11-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12018048-B2 Anthelmintic depsipeptide compounds VIP, DNPEP, DPEP1 MEN1 1915/4885KMT2A 3127/4885NPSR1 252/4885
US-20170022253-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS VIP, PREP, DNPEP MEN1 1902/4885KMT2A 2407/4885NPSR1 252/4885
US-11382949-B2 Anthelmintic depsipeptide compounds ENPP2, ROCK2, RRP12 MEN1 2930/4885KMT2A 1158/4885NPSR1 165/4885
US-20170233438-A1 ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS VIP, PREP, DNPEP MEN1 1735/4885KMT2A 2523/4885NPSR1 209/4885
US-10081656-B2 Anthelmintic depsipeptide compounds VIP, PREP, DNPEP MEN1 1902/4885KMT2A 2407/4885NPSR1 252/4885
US-12286455-B2 Anthelmintic depsipeptide compounds VIP, PREP, DNPEP MEN1 1902/4885KMT2A 2407/4885NPSR1 252/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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