Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20164107 | 0.90 | GPR119 (0.47) | GPR119RORCNAMPTUSP30IDO1 | |
| SCHEMBL18249638 | 0.90 | GPR119 (0.47) | GPR119RORCNAMPTUSP30IDO1 | |
| SCHEMBL31602843 | 0.82 | GPR119 (0.43) | GPR119RORCNAMPTUSP30IDO1 | |
| SCHEMBL20164094 | 0.81 | CES2 (0.38) | KMT2A | |
| SCHEMBL18249627 | 0.81 | CES2 (0.41) | KMT2A | |
| SCHEMBL18249668 | 0.81 | DPP4 (0.44) | GPR119RORCNAMPTUSP30IDO1 | |
| SCHEMBL18249631 | 0.79 | MMP13 (0.40) | GPR119RORCUSP30MAP3K14DPP4 | |
| SCHEMBL18249663 | 0.79 | DPP4 (0.45) | GPR119RORCUSP30DPP4 | |
| SCHEMBL18249647 | 0.78 | HDAC1 (0.39) | GPR119RORCUSP30MAP3K14DPP4 | |
| SCHEMBL18249576 | 0.78 | GPR119 (0.47) | GPR119RORCNAMPTUSP30IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3297987-A1 | NOVEL AZETIDINE DERIVATIVES USEFUL AS MODULATORS OF CORTICAL CATHECOLAMINERGIC NEUROTRANSMISSION | Integrative Research Laboratories Sweden AB (SE) | 2018-03-28 | — | — | EP | disclosed |
| WO-2016185032-A1 | NOVEL AZETIDINE DERIVATIVES USEFUL AS MODULATORS OF CORTICAL CATHECOLAMINERGIC NEUROTRANSMISSION | INTEGRATIVE RESEARCH LABORATORIES SWEDEN AB (SE) | 2016-11-24 | — | — | WO | disclosed |