Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | HCK | P08631 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | FRK | P42685 | 1/20 | 0.39 |
| ▸ | BLK | P51451 | 1/20 | 0.39 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18250073 | 0.76 | MTNR1A (0.41) | MTNR1AMTNR1BMAPTFYNLYN | |
| SCHEMBL27916161 | 0.71 | PYCR1 (0.43) | PYCR1MAPTPOLBTSHRMAPK1 | |
| SCHEMBL28462816 | 0.69 | LPAR1 (0.33) | MAPTTHRBPOLBGAAHTT | |
| SCHEMBL8163718 | 0.69 | HTR2A (0.63) | PYCR1POLBKDM4ETDP1 | |
| SCHEMBL1125103 | 0.69 | PYCR1 (0.53) | PYCR1MAPTTHRBTSHRMAPK1 | |
| SCHEMBL3484403 | 0.69 | PYCR1 (0.53) | PYCR1MAPTTHRBTSHRMAPK1 | |
| SCHEMBL30423333 | 0.69 | PYCR1 (0.53) | PYCR1MAPTTHRBTSHRMAPK1 | |
| SCHEMBL29002529 | 0.69 | TSHR (0.46) | PYCR1MAPTTSHRMAPK1GAA | |
| SCHEMBL29002566 | 0.69 | PYCR1 (0.41) | PYCR1MAPTPOLBTSHRMAPK1 | |
| SCHEMBL30415099 | 0.68 | SLC6A4 (0.57) | PYCR1MAPTTHRBTSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107849050-B | Compound (I) | 爱丁堡大学董事会 | 2020-10-13 | — | — | CN | disclosed |
| US-10294227-B2 | Compounds | UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2019-05-21 | — | — | US | disclosed |
| US-20180127422-A1 | COMPOUNDS | UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2018-05-10 | — | — | US | disclosed |
| EP-3298015-A1 | COMPOUNDS | The University Court of the University of Edinburgh (GB) | 2018-03-28 | — | — | EP | disclosed |
| WO-2016185160-A1 | COMPOUNDS | THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2016-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127422-A1 | COMPOUNDS | CBR3, OR10J3, CBR1 | MTNR1A 247/4885PYCR1 1255/4885MTNR1B 402/4885 |
| US-10294227-B2 | Compounds | CBR3, OR10J3, CBR1 | MTNR1A 194/4885PYCR1 1157/4885MTNR1B 323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.