SCHEMBL1825035

SCHEMBL1825035

CC1=Cc2c(-c3ccccc3)cccc2C1[Si](C)(C)Cl

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDCD1 Q15116 1/20 0.33
CD274 Q9NZQ7 1/20 0.33
CYP2A6 P11509 1/20 0.32
ADRA2A P08913 2/20 0.31
ADRA2B P18089 2/20 0.31
ADRA2C P18825 2/20 0.31
CHRNB2 P17787 1/20 0.31
CHRNA4 P43681 1/20 0.31
NPC1 O15118 1/20 0.31
ALDH1A1 P00352 1/20 0.31
HPGD P15428 1/20 0.31
TSHR P16473 1/20 0.31
RAB9A P51151 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
HTR2B P41595 3/20 0.31
TMEM97 Q5BJF2 3/20 0.31
HTR1A P08908 2/20 0.31
HTR7 P34969 2/20 0.31
SIGMAR1 Q99720 2/20 0.31
PTGS1 P23219 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7051179 0.91 PDCD1 (0.33) PDCD1CD274CYP2A6ADRA2AADRA2B
SCHEMBL7048688 0.91 PDCD1 (0.34) PDCD1CD274CYP2A6ADRA2AADRA2B
SCHEMBL15827904 0.90 ADORA3 (0.32) NPC1ALDH1A1RAB9AADORA3ENPP1
SCHEMBL7050759 0.89 PDCD1 (0.35) PDCD1CD274ADRA2AADRA2BADRA2C
SCHEMBL61908 0.88 PDCD1 (0.34) PDCD1CD274CYP2A6ADRA2AADRA2B
SCHEMBL29366427 0.88 PDCD1 (0.34) PDCD1CD274CYP2A6ADRA2AADRA2B
SCHEMBL7053161 0.88 PDCD1 (0.34) PDCD1CD274ADRA2AADRA2BADRA2C
SCHEMBL7054636 0.87 PDCD1 (0.30) PDCD1CD274
SCHEMBL7053136 0.86 PDCD1 (0.35) PDCD1CD274CYP2A6ADRA2AADRA2B
SCHEMBL7048706 0.85 PDCD1 (0.31) PDCD1CD274CYP2A6CHRNB2CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3539993-A1 CYCLOPROPYL SUBSTITUTED METALLOCENE CATALYSTS ExxonMobil Chemical Patents Inc. (US) 2019-09-18 EP disclosed
EP-3022233-B1 CYCLOPROPYL SUBSTITUTED METALLOCENE CATALYSTS EXXONMOBIL CHEMICAL PATENTS INC (US) 2019-05-01 EP disclosed
US-20180066083-A1 Cyclopropyl Substituted Metallocene Catalysts EXXONMOBIL CHEMICAL PATENTS INC. 2018-03-08 US disclosed
US-9834628-B2 Cyclopropyl substituted metallocene catalysts EXXONMOBIL CHEMICAL PATENTS INC. (US) 2017-12-05 US disclosed
EP-3063184-B1 ASYMMETRIC CATALYSTS FOR OLEFIN POLYMERISATION EXXONMOBIL CHEMICAL PATENTS INC (US) 2017-11-29 EP disclosed
US-9790240-B2 Ligand compound, a preparation method thereof, a transition metal compound, and a preparation method thereof LG CHEM, LTD. (KR) 2017-10-17 US disclosed
EP-2918591-B1 NOVEL LIGAND COMPOUND, PREPARATION METHOD THEREFOR, TRANSITION METAL COMPOUND, AND PREPARATION METHOD THEREFOR LG CHEMICAL LTD (KR) 2017-09-13 EP disclosed
EP-3063184-A1 ASYMMETRIC POLYPROPYLENE CATALYSTS ExxonMobil Chemical Patents Inc. (US) 2016-09-07 EP disclosed
US-20160215004-A1 A NOVEL LIGAND COMPOUND, A PREPARATION METHOD THEREOF, A TRANSITION METAL COMPOUND, AND A PREPARATION METHOD THEREOF LG CHEM, LTD. (KR) 2016-07-28 US disclosed
US-9376559-B2 Reverse staged impact copolymers EXXONMOBIL CHEMICAL PATENTS INC. (US) 2016-06-28 US disclosed
EP-0834519-B1 CATALYST FOR POLYOLEFIN PRODUCTION AND PROCESS FOR PRODUCING POLYOLEFIN JAPAN POLYOLEFINS CO LTD (JP) 2002-03-06 EP disclosed
EP-1157027-A1 HETEROCYCLIC METALLOCENE COMPOUNDS AND USE THEREOF IN CATALYST SYSTEMS FOR PRODUCING OLEFIN POLYMERS Basell Technology Company B.V. (NL) 2001-11-28 EP disclosed
WO-2001047939-A1 HETEROCYCLIC METALLOCENE COMPOUNDS AND USE THEREOF IN CATALYST SYSTEMS FOR PRODUCING OLEFIN POLYMERS BASELL TECHNOLOGY COMPANY B.V. (NL) 2001-07-05 WO disclosed
US-6255515-B1 COORDINATION POLYMERIZATION CATALYSTS MITSUBISHI CHEMICAL CORPORATION (JP) 2001-07-03 US disclosed
US-6121182-A A METALLOCENE CATALYST FOR POLYMERIZATION OF ISOTACTIC POLYOLEFINS WITH HIGH RIGIDITY AND HIGH MELTING POINT, USEFUL AS INDUSTRIAL MATERIAL FOR AUTOMOBILES JAPAN POLYOLAFINS CO., LTD. (JP) 2000-09-19 US disclosed
EP-0985674-A1 ORGANIC COMPOUNDS CONTAINING SILICON OR GERMANIUM, TRANSITION METAL COMPLEXES, CATALYST FOR $g(a)-OLEFIN POLYMERIZATION, AND PROCESSES FOR PRODUCING $g(a)-OLEFIN POLYMERS MITSUBISHI CHEMICAL CORPORATION (JP) 2000-03-15 EP disclosed
EP-0834519-A1 CATALYST FOR POLYOLEFIN PRODUCTION AND PROCESS FOR PRODUCING POLYOLEFIN Japan Polyolefins Co., Ltd. (JP) 1998-04-08 EP disclosed
US-5612428-A CATALYTIC POLYMERIZATION WITH COORDINATION COMPLEXES WITH GROUP IVB METALS AND COCATALYSTS HOECHST AKTIENGESELLSCHAFT (DE) 1997-03-18 US disclosed
US-5576260-A POLYMERIZATION CATALYSTS FOR OLEFINS HOECHST AKTIENGESELLSCHAFT (DE) 1996-11-19 US disclosed
US-5532396-A HAS TWO INDENYL LIGANDS WITH DIFFERENT SUBSTITUTION PATTERNS ON THE SIX-MEMBERED RINGS. LIGANDS ARE JOINED BY DIVALENT GROUP CONNECTING FIVE-MEMBERED RINGS. METAL IS FROM GROUP /IVB/, /VB/ OR /VIB/. OLEFIN POLYMERIZATION CATALYST HOECHST AKTIENGESELLSCHAFT (DE) 1996-07-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180066083-A1 Cyclopropyl Substituted Metallocene Catalysts CPNE4, TIMM13, NECTIN4 PDCD1 239/4885CD274 86/4885CYP2A6 331/4885
US-20160215004-A1 A NOVEL LIGAND COMPOUND, A PREPARATION METHOD THEREOF, A TRANSITION METAL COMPOUND, AND A PREPARATION METHOD THEREOF CD40LG, OSTC, TNFSF10 PDCD1 177/4885CD274 7/4885CYP2A6 1587/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.