Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 3/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1817374 | 1.00 | ITGB1 (0.42) | ITGB1ITGA4POLBITGB3ITGA2B | |
| SCHEMBL7384383 | 1.00 | ITGB1 (0.42) | ITGB1ITGA4POLBITGB3ITGA2B | |
| Tromethamine SCHEMBL7106361 | 0.95 | ITGB1 (0.39) | ITGB1ITGA4POLBITGB3ITGA2B | |
| SCHEMBL7102059 | 0.95 | ITGB1 (0.49) | ITGB1ITGA4 | |
| SCHEMBL7417699 | 0.95 | ITGB1 (0.49) | ITGB1ITGA4 | |
| SCHEMBL7101082 | 0.95 | ITGB1 (0.49) | ITGB1ITGA4 | |
| SCHEMBL7099781 | 0.94 | ITGB1 (0.49) | ITGB1ITGA4 | |
| SCHEMBL7100997 | 0.91 | HIF1A (0.40) | ITGB3SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL7416413 | 0.91 | ITGB1 (0.40) | ITGB1ITGA4POLBMAPTHPGD | |
| SCHEMBL7105287 | 0.91 | ITGB1 (0.40) | ITGB1ITGA4POLBMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4686029-B2 | — | — | 2011-05-18 | — | — | JP | claimed |
| EP-1183241-B1 | SPIROIMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM | AVENTIS PHARMA GMBH (DE) | 2003-09-17 | — | — | EP | claimed |
| JP-2002544261-A | — | — | 2002-12-24 | — | — | JP | claimed |
| US-6399643-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-06-04 | — | — | US | claimed |
| EP-1183241-A1 | SPIROIMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM | Aventis Pharma Deutschland GmbH (DE) | 2002-03-06 | — | — | EP | claimed |
| WO-2000069831-A1 | SPIROIMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-23 | — | — | WO | claimed |
| EP-1687397-A2 | IMPROVED APPARATUS AND METHOD FOR IDENTIFICATION OF BIOMOLECULES, IN PARTICULAR NUCLEIC ACID SEQUENCES, PROTEINS, AND ANTIGENS AND ANTIBODIES | Davis, Randall W. (US) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005040343-A2 | IMPROVED APPARATUS AND METHOD FOR IDENTIFICATION OF BIOMOLECULES, IN PARTICULAR NUCLEIC ACID SEQUENCES, PROTEINS, AND ANTIGENS AND ANTIBODIES | DAVIS RANDALL W (US) | 2005-05-06 | — | — | WO | disclosed |
| US-20050079598-A1 | Apparatus and method for identification of biomolecules, in particular nucleic acid sequences, proteins, and antigens and antibodies | DAVIS RANDALL W (US) | 2005-04-14 | — | — | US | disclosed |
| EP-1183241-B1 | SPIROIMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM | AVENTIS PHARMA GMBH (DE) | 2003-09-17 | — | — | EP | disclosed |
| US-6399643-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-06-04 | — | — | US | disclosed |
| EP-1183241-A1 | SPIROIMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM | Aventis Pharma Deutschland GmbH (DE) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069831-A1 | SPIROIMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-23 | — | — | WO | disclosed |
| US-4833243-A | BENZOOXAZOLES OR BENZOTHIAZOLES | BAYER AKTIENGESELLSCHAFT (DE) | 1989-05-23 | — | — | US | disclosed |