Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.36 |
| ▸ | ITGAV | P06756 | 3/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7106468 | 0.95 | ITGB1 (0.41) | — | |
| SCHEMBL7416413 | 0.93 | ITGB1 (0.40) | HIF1AMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7105287 | 0.93 | ITGB1 (0.40) | HIF1AMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL1820746 | 0.92 | LMNA (0.37) | ALDH1A1RAB9ANPC1ITGB3ITGAV | |
| SCHEMBL7107550 | 0.92 | LMNA (0.37) | ALDH1A1RAB9ANPC1ITGB3ITGAV | |
| SCHEMBL7103777 | 0.92 | LMNA (0.37) | RAB9ANPC1ITGB3ITGAV | |
| SCHEMBL7384383 | 0.91 | ITGB1 (0.42) | ALDH1A1MAPTSMN1; SMN2ITGB3 | |
| SCHEMBL1825542 | 0.91 | ITGB1 (0.42) | ALDH1A1MAPTSMN1; SMN2ITGB3 | |
| SCHEMBL1817374 | 0.91 | ITGB1 (0.42) | ALDH1A1MAPTSMN1; SMN2ITGB3 | |
| SCHEMBL1821359 | 0.90 | HIF1A (0.36) | HIF1APTGER3MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183241-B1 | SPIROIMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM | AVENTIS PHARMA GMBH (DE) | 2003-09-17 | — | — | EP | disclosed |
| US-6399643-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-06-04 | — | — | US | disclosed |