Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 8/20 | 0.35 |
| ▸ | VHL | P40337 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.31 |
| ▸ | GSK3B | P49841 | 2/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28540594 | 0.90 | PARG (0.35) | PARGVHLEPHX2MEN1KMT2A | |
| SCHEMBL19987782 | 0.85 | PARG (0.35) | PARGVHLEPHX2MEN1KMT2A | |
| SCHEMBL1320181 | 0.78 | VHL (0.41) | PARGVHLEPHX2MEN1KMT2A | |
| SCHEMBL28540592 | 0.78 | PARG (0.35) | PARGVHLEPHX2MEN1KMT2A | |
| SCHEMBL18256114 | 0.78 | VHL (0.39) | PARGVHLEPHX2MEN1KMT2A | |
| SCHEMBL1320408 | 0.75 | VHL (0.41) | PARGVHLEPHX2MEN1KMT2A | |
| SCHEMBL18256181 | 0.69 | VHL (0.38) | PARGVHLEPHX2MEN1KMT2A | |
| SCHEMBL1941686 | 0.68 | KMT2A (0.51) | VHLEPHX2MEN1KMT2AALDH1A1 | |
| SCHEMBL21072493 | 0.68 | VDR (0.31) | — | |
| SCHEMBL18255919 | 0.67 | CHI3L1 (0.40) | NPC1RAB9ACHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299371-A1 | HYDROXYL PURINE COMPOUNDS AND USE THEREOF | GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD (CN) | 2018-03-28 | — | — | EP | disclosed |
| WO-2016184312-A1 | HYDROXYL PURINE COMPOUNDS AND USE THEREOF | 南京明德新药研发股份有限公司 | 2016-11-24 | — | — | WO | disclosed |