Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.74 |
| ▸ | KDR | P35968 | 5/20 | 0.73 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.71 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | CASP3 | P42574 | 1/20 | 0.62 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.62 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.62 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18257156 | 0.85 | KDR (0.74) | TDP1KDRHDAC6HTTL3MBTL1 | |
| SCHEMBL30061443 | 0.85 | TDP1 (1.00) | TDP1KDRHDAC6HTTL3MBTL1 | |
| SCHEMBL15328429 | 0.85 | TDP1 (1.00) | TDP1KDRHDAC6HTTL3MBTL1 | |
| SCHEMBL29205661 | 0.84 | KDR (1.00) | TDP1KDRHDAC6HTTL3MBTL1 | |
| SCHEMBL18257152 | 0.84 | KDR (0.73) | TDP1KDRHDAC6HTTL3MBTL1 | |
| SCHEMBL31398643 | 0.84 | KDR (0.73) | TDP1KDRHDAC6HTTL3MBTL1 | |
| SCHEMBL19631488 | 0.83 | HDAC6 (1.00) | TDP1KDRHDAC6HTTL3MBTL1 | |
| SCHEMBL29647754 | 0.83 | HDAC6 (1.00) | TDP1KDRHDAC6HTTL3MBTL1 | |
| SCHEMBL6645868 | 0.82 | HTT (1.00) | TDP1KDRHDAC6HTTL3MBTL1 | |
| SCHEMBL15270551 | 0.81 | HDAC6 (0.79) | TDP1KDRHDAC6HTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10457662-B2 | Substituted amides for treating and preventing cancer | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-10-29 | — | — | US | disclosed |
| US-10457662-B2 | Substituted amides for treating and preventing cancer | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-10-29 | — | — | US | disclosed |
| US-20180282296-A1 | COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING CANCER | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2018-10-04 | — | — | US | disclosed |
| WO-2016187544-A1 | COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING CANCER | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180282296-A1 | COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING CANCER | NNT, NQO1, NAMPT | TDP1 2509/4885KDR 4802/4885HDAC6 46/4885 |
| US-10457662-B2 | Substituted amides for treating and preventing cancer | NQO1, NNT, SIRT1 | TDP1 3468/4885KDR 4310/4885HDAC6 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.