Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDH1 | P12830 | 1/20 | 1.00 |
| ▸ | APC | P25054 | 1/20 | 1.00 |
| ▸ | CTNNB1 | P35222 | 1/20 | 1.00 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 1.00 |
| ▸ | GAA | P10253 | 4/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.73 |
| ▸ | HPGD | P15428 | 3/20 | 0.73 |
| ▸ | RAB9A | P51151 | 3/20 | 0.73 |
| ▸ | NPC1 | O15118 | 2/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.72 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.61 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.61 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15665468 | 0.95 | CDH1 (0.91) | CDH1APCCTNNB1TCF7L2GAA | |
| SCHEMBL9953732 | 0.90 | CDH1 (0.81) | CDH1APCCTNNB1TCF7L2GAA | |
| SCHEMBL15665863 | 0.85 | HPGD (0.93) | CDH1APCCTNNB1TCF7L2GAA | |
| SCHEMBL15666427 | 0.85 | HPGD (0.93) | CDH1APCCTNNB1TCF7L2GAA | |
| SCHEMBL1258992 | 0.85 | ALDH1A1 (0.76) | CDH1APCCTNNB1TCF7L2GAA | |
| SCHEMBL6291531 | 0.85 | ALDH1A1 (1.00) | CDH1APCCTNNB1TCF7L2GAA | |
| SCHEMBL30555665 | 0.85 | ALDH1A1 (1.00) | CDH1APCCTNNB1TCF7L2GAA | |
| SCHEMBL14144079 | 0.84 | ALDH1A1 (0.73) | CDH1APCCTNNB1TCF7L2GAA | |
| SCHEMBL15666702 | 0.84 | ALDH1A1 (1.00) | CDH1APCCTNNB1TCF7L2GAA | |
| SCHEMBL7262881 | 0.84 | ALDH1A1 (0.73) | CDH1APCCTNNB1TCF7L2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10273246-B2 | Methods and compositions of substituted 5H-[1,2,5] oxadiazolo [3′,4′:5,6] pyrazino[2,3-B] indole analogs as inhibitors of β-catenin/T-cell factor protein-protein interactions | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2019-04-30 | — | — | US | disclosed |
| US-20180134729-A1 | METHODS AND COMPOSITIONS OF SUBSTITUTED 5H-[1,2,5] OXADIAZOLO [3',4':5,6] PYRAZINO[2,3-B] INDOLE ANALOGS AS INHIBITORS OF BETA-CATENIN/T-CELL FACTOR PROTEIN-PROTEIN INTERACTIONS | UNIVERSITY OF UTAH | 2018-05-17 | — | — | US | disclosed |
| WO-2016187050-A1 | METHODS AND COMPOSITIONS OF SUBSTITUTED 5H-[1,2,5]OXADIAZOLO[3',4':5,6] PYRAZIONO[2,3-B]INDOLE ANALOGS AS INHIBITORS OF BETA-CATENIN/T-CELL FACTOR PROTEIN-PROTEIN INTERACTIONS | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2016-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134729-A1 | METHODS AND COMPOSITIONS OF SUBSTITUTED 5H-[1,2,5] OXADIAZOLO [3',4':5,6] PYRAZINO[2,3-B] INDOLE ANALOGS AS INHIBITORS OF BETA-CATENIN/T-CELL FACTOR PROTEIN-PROTEIN INTERACTIONS | CTNNB1, CTNNBL1, WNT3A | CDH1 2090/4885APC 16/4885CTNNB1 1/4885 |
| US-10273246-B2 | Methods and compositions of substituted 5H-[1,2,5] oxadiazolo [3′,4′:5,6] pyrazino[2,3-B] indole analogs as inhibitors of β-catenin/T-cell factor protein-protein interactions | CTNNB1, CTNNBL1, WNT3A | CDH1 2064/4885APC 16/4885CTNNB1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.