SCHEMBL1826293

SCHEMBL1826293

NC(=O)Nc1cc2ccccc2o1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FLT3 P36888 1/20 0.55
NPC1 O15118 8/20 0.53
RAB9A P51151 7/20 0.53
SMN1; SMN2 Q16637 5/20 0.53
TP53 P04637 4/20 0.53
PKM P14618 2/20 0.53
NFKB1 P19838 1/20 0.53
NFKB2 Q00653 1/20 0.53
RELA Q04206 1/20 0.53
MEN1 O00255 3/20 0.49
KMT2A Q03164 3/20 0.49
TSHR P16473 2/20 0.49
MAPK1 P28482 1/20 0.49
HSD17B10 Q99714 2/20 0.48
LMNA P02545 3/20 0.48
ALDH1A1 P00352 3/20 0.48
TAS1R3 Q7RTX0 1/20 0.48
TAS1R1 Q7RTX1 1/20 0.48
MAOB P27338 1/20 0.47
KDM4E B2RXH2 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10823736 0.84 NPC1 (0.54) FLT3NPC1RAB9ASMN1; SMN2TP53
SCHEMBL562259 0.82 FLT3 (0.46) FLT3NPC1RAB9ASMN1; SMN2TP53
SCHEMBL13652067 0.82 SMN1; SMN2 (0.64) FLT3NPC1RAB9ASMN1; SMN2TP53
SCHEMBL3867380 0.81 TAS1R3 (0.51) FLT3NPC1RAB9ASMN1; SMN2TP53
SCHEMBL3800547 0.81 NPC1 (0.51) FLT3NPC1RAB9ASMN1; SMN2TP53
Hydrochloric Acid SCHEMBL3794175 0.79 NPC1 (0.50) FLT3NPC1RAB9ASMN1; SMN2TP53
SCHEMBL28563825 0.79 SMN1; SMN2 (0.74) NPC1RAB9ASMN1; SMN2PKMMEN1
SCHEMBL5613922 0.79 HPGD (0.53) FLT3NPC1RAB9ASMN1; SMN2TP53
SCHEMBL1059656 0.79 NPC1 (0.66) NPC1RAB9ASMN1; SMN2TP53PKM
SCHEMBL3871617 0.79 TAS1R3 (0.49) FLT3NPC1RAB9ASMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0779291-B1 Heterocyclylcarbonyl substituted benzofuranyl-ureas BAYER AG (DE) 2001-10-10 EP claimed
US-5922740-A ANTIINFLAMMATORY AGENTS BAYER AKTIENGESELLSCHAFT (DE) 1999-07-13 US claimed
EP-0779291-A1 Heterocyclylcarbonyl substituted benzofuranyl-ureas BAYER AG (DE) 1997-06-18 EP claimed
US-11286280-B2 Melanocortin-1 receptor-specific peptides for cytokine storm and inflammation therapy PALATIN TECHNOLOGIES, INC. (US) 2022-03-29 US disclosed
US-20200339631-A1 Melanocortin-1 Receptor-Specific Peptides for Cytokine Storm and Inflammation Therapy PALATIN TECHNOLOGIES INC (US) 2020-10-29 US disclosed
US-10711039-B2 Melanocortin receptor-specific peptide with C-terminal naphthylalanine PALATIN TECHNOLOGIES, INC. (US) 2020-07-14 US disclosed
EP-2504352-B1 MELANOCORTIN-1 RECEPTOR-SPECIFIC CYCLIC PEPTIDES PALATIN TECHNOLOGIES INC (US) 2018-11-14 EP disclosed
US-10106578-B2 Melanocortin-1 receptor-specific linear peptides PALATIN TECHNOLOGIES, INC. (US) 2018-10-23 US disclosed
US-10017539-B2 Melanocortin-1 receptor-specific cyclic hexapeptides PALATIN TECHNOLOGIES, INC. (US) 2018-07-10 US disclosed
US-20180148478-A1 Melanocortin Receptor-Specific Peptide with C-Terminal Naphthylalanine PALATIN TECHNOLOGIES INC (US) 2018-05-31 US disclosed
US-20170145056-A1 Melanocortin-1 Receptor-Specific Linear Peptides PALATIN TECHNOLOGIES INC (US) 2017-05-25 US disclosed
EP-0779291-B1 Heterocyclylcarbonyl substituted benzofuranyl-ureas BAYER AG (DE) 2001-10-10 EP disclosed
US-6277878-B1 ANTIINFLAMMATORY AGENTS; ANALGESICS PFIZER INC 2001-08-21 US disclosed
EP-0985666-A1 Substituted indole compounds as COX-2 inhibitors PFIZER INC. (US) 2000-03-15 EP disclosed
US-5922740-A ANTIINFLAMMATORY AGENTS BAYER AKTIENGESELLSCHAFT (DE) 1999-07-13 US disclosed
US-5922740-A ANTIINFLAMMATORY AGENTS BAYER AKTIENGESELLSCHAFT (DE) 1999-07-13 US disclosed
US-5922740-A ANTIINFLAMMATORY AGENTS BAYER AKTIENGESELLSCHAFT (DE) 1999-07-13 US disclosed
EP-0779291-A1 Heterocyclylcarbonyl substituted benzofuranyl-ureas BAYER AG (DE) 1997-06-18 EP disclosed
EP-0779291-A1 Heterocyclylcarbonyl substituted benzofuranyl-ureas BAYER AG (DE) 1997-06-18 EP disclosed
EP-0779291-A1 Heterocyclylcarbonyl substituted benzofuranyl-ureas BAYER AG (DE) 1997-06-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10711039-B2 Melanocortin receptor-specific peptide with C-terminal naphthylalanine MC1R, MC3R, MC4R FLT3 2025/4885NPC1 1411/4885RAB9A 211/4885
US-10106578-B2 Melanocortin-1 receptor-specific linear peptides MC1R, MC5R, MC3R FLT3 1589/4885NPC1 3648/4885RAB9A 1451/4885
US-11286280-B2 Melanocortin-1 receptor-specific peptides for cytokine storm and inflammation therapy MC3R, MC1R, MC2R FLT3 1496/4885NPC1 3165/4885RAB9A 1797/4885
US-10017539-B2 Melanocortin-1 receptor-specific cyclic hexapeptides MC1R, MC3R, MC5R FLT3 786/4885NPC1 2800/4885RAB9A 287/4885
US-20170145056-A1 Melanocortin-1 Receptor-Specific Linear Peptides MC1R, MC5R, MC3R FLT3 1589/4885NPC1 3648/4885RAB9A 1451/4885
US-20200339631-A1 Melanocortin-1 Receptor-Specific Peptides for Cytokine Storm and Inflammation Therapy MC3R, MC1R, MC2R FLT3 1496/4885NPC1 3165/4885RAB9A 1797/4885
US-20180148478-A1 Melanocortin Receptor-Specific Peptide with C-Terminal Naphthylalanine MC1R, MC3R, MC4R FLT3 2025/4885NPC1 1411/4885RAB9A 211/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.