Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | F12 | P00748 | 1/20 | 0.48 |
| ▸ | PTPRC | P08575 | 1/20 | 0.47 |
| ▸ | PTPRF | P10586 | 1/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.47 |
| ▸ | PTPRB | P23467 | 1/20 | 0.47 |
| ▸ | PTPRE | P23469 | 1/20 | 0.47 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3794175 | 0.98 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL10823736 | 0.86 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL1059656 | 0.81 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL13652067 | 0.81 | SMN1; SMN2 (0.64) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL1826293 | 0.81 | FLT3 (0.55) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL1066448 | 0.80 | RAB9A (0.60) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL11388357 | 0.79 | KDM4E (0.60) | NPC1RAB9ASMN1; SMN2TP53MAOB | |
| SCHEMBL11396751 | 0.79 | MAOB (0.71) | NPC1RAB9ASMN1; SMN2PKMMAOB | |
| SCHEMBL5613922 | 0.78 | HPGD (0.53) | NPC1RAB9ASMN1; SMN2TP53PKM | |
| SCHEMBL3871617 | 0.78 | TAS1R3 (0.49) | NPC1RAB9ASMN1; SMN2TP53PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166849-A1 | SUBSTITUTED PYRAZOLE COMPOUNDS | Miikana Therapeutics, Inc. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154026-A1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MIIKANA THERAPEUTICS, INC. (US) | 2008-12-18 | — | — | WO | disclosed |