Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18260419 | 0.95 | CYP2D6 (0.34) | CYP2D6GAA | |
| SCHEMBL5375594 | 0.70 | KMT2A (0.34) | CYP2D6GAA | |
| SCHEMBL679504 | 0.70 | FPR2 (0.36) | CYP2D6 | |
| SCHEMBL31145987 | 0.67 | ATR (0.37) | — | |
| SCHEMBL18260522 | 0.66 | KDM4E (0.39) | — | |
| SCHEMBL29565434 | 0.66 | KDM4E (0.39) | — | |
| SCHEMBL29565827 | 0.64 | KDM4E (0.38) | — | |
| SCHEMBL16856891 | 0.64 | KDM4E (0.38) | — | |
| SCHEMBL17980670 | 0.62 | L3MBTL1 (0.50) | CYP2D6 | |
| SCHEMBL8770893 | 0.62 | APP (0.39) | CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3303348-A1 | NAPHTHYRIDINE COMPOUNDS AS JAK KINASE INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2018-04-11 | — | — | EP | disclosed |
| WO-2016191524-A1 | NAPHTHYRIDINE COMPOUNDS AS JAK KINASE INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2016-12-01 | — | — | WO | disclosed |