SCHEMBL18264306

SCHEMBL18264306

COc1cc(F)c([C@@H]2Cn3ccnc3[C@H]2NC(=O)O)c(F)c1

nearest known ligand 0.48

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
FPR2 P25090 20/20 0.48
FPR1 P21462 17/20 0.48
CYP3A4 P08684 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18264305 1.00 FPR2 (0.48) FPR2FPR1CYP3A4
SCHEMBL18264289 0.85 FPR2 (0.64) FPR2FPR1
SCHEMBL18264291 0.85 FPR2 (0.64) FPR2FPR1
SCHEMBL18270477 0.84 FPR2 (0.45) FPR2FPR1
SCHEMBL18264195 0.80 FPR2 (0.44) FPR2FPR1
SCHEMBL18264196 0.80 FPR2 (0.44) FPR2FPR1
SCHEMBL20177826 0.79 FPR2 (0.36) FPR2FPR1
SCHEMBL20581619 0.77 FPR1 (0.50) FPR2FPR1
SCHEMBL18264270 0.73 FPR2 (0.53) FPR2FPR1
SCHEMBL18264269 0.73 FPR2 (0.53) FPR2FPR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180207153-A1 UREA DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF KYORIN PHARMACEUTICAL CO., LTD. (JP) 2018-07-26 US disclosed
EP-3331884-A1 UREA DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF Kyorin Pharmaceutical Co., Ltd. (JP) 2018-06-13 EP disclosed
WO-2016189876-A1 UREA DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF KYORIN PHARMACEUTICAL CO., LTD. (JP) 2016-12-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180207153-A1 UREA DERIVATIVE OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF FPR1, FPR2, SAAL1 FPR2 2/4885FPR1 1/4885CYP3A4 3424/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.