Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | CCR3 | P51677 | 2/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | RET | P07949 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | PTGES | O14684 | 1/20 | 0.30 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2716526 | 0.94 | SCN9A (0.38) | SCN9ACCR3NR1H4ALDH1A1RET | |
| SCHEMBL2714698 | 0.82 | SCN9A (0.48) | SCN9ACCR3ALDH1A1KDM4EMEN1 | |
| SCHEMBL2714301 | 0.82 | PTGES (0.40) | SCN9ACCR3NR1H4ALDH1A1MMP13 | |
| SCHEMBL2713499 | 0.82 | SCN9A (0.38) | SCN9ACCR3ALDH1A1KDM4EMEN1 | |
| SCHEMBL2717877 | 0.81 | CHRNB2 (0.37) | SCN9ACCR3ALDH1A1RETKDM4E | |
| SCHEMBL2714754 | 0.80 | SCN9A (0.37) | SCN9AALDH1A1MEN1KMT2ACHRNB2 | |
| SCHEMBL2716387 | 0.78 | SCN9A (0.41) | SCN9ACCR3ALDH1A1KMT2AMAPT | |
| SCHEMBL2716573 | 0.77 | PPARG (0.41) | NR1H4 | |
| SCHEMBL18266581 | 0.77 | LMNA (0.41) | — | |
| SCHEMBL2717500 | 0.77 | PPARG (0.40) | SCN9ANR1H4ALDH1A1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630122-B1 | ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC (JP) | 2016-11-30 | — | — | EP | disclosed |