Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 6/20 | 0.41 |
| ▸ | WDR5 | P61964 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 2/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.38 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2716384 | 0.93 | SCN9A (0.53) | SCN9AROCK2SCN3AWDR5LMNA | |
| SCHEMBL2715174 | 0.85 | SCN9A (0.51) | SCN9AWDR5LMNAKCNH2KCNB1 | |
| SCHEMBL2714516 | 0.84 | SCN9A (0.49) | SCN9AROCK2WDR5KCNB1PPARD | |
| SCHEMBL2713199 | 0.83 | SCN9A (0.48) | SCN9AROCK2SCN3AKCNB1 | |
| SCHEMBL2715099 | 0.83 | SCN9A (0.56) | SCN9AROCK2SCN3ACCR3 | |
| SCHEMBL2714086 | 0.83 | ROCK2 (0.50) | SCN9AROCK2SCN3AWDR5LMNA | |
| SCHEMBL2715396 | 0.81 | SCN9A (0.48) | SCN9AROCK2SCN3AKCNB1PTGES | |
| SCHEMBL2714916 | 0.81 | EPHX2 (0.53) | SCN9AKCNB1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL2719098 | 0.80 | SCN9A (0.51) | SCN9AKCNB1MAPTPTGESPPARD | |
| SCHEMBL18266303 | 0.80 | SCN9A (0.47) | SCN9AROCK2LMNAKCNB1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2630122-B1 | ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC (JP) | 2016-11-30 | — | — | EP | disclosed |