Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL415807 | 1.00 | CHRNA7 (0.42) | CHRNA7CHRM2CHRM1CHRNA4CYP2D6 | |
| SCHEMBL18268169 | 1.00 | CHRNA7 (0.42) | CHRNA7CHRM2CHRM1CHRNA4CYP2D6 | |
| Hydrochloric Acid SCHEMBL10978368 | 0.98 | CHRNA7 (0.41) | CHRNA7CHRM2CHRM1CHRNA4CYP2D6 | |
| SCHEMBL2420280 | 0.88 | — | — | |
| SCHEMBL7318990 | 0.88 | — | — | |
| SCHEMBL7324063 | 0.81 | CHRNA7 (0.39) | CHRNA7CHRM2CHRM1CHRNA4CYP2D6 | |
| SCHEMBL13617347 | 0.81 | CHRNA7 (0.39) | CHRNA7CHRM2CHRM1CHRNA4CYP2D6 | |
| SCHEMBL28703379 | 0.79 | CHRNA7 (0.38) | CHRNA7CHRM2CHRM1CHRNA4CYP2D6 | |
| SCHEMBL7328436 | 0.78 | CHRNA7 (0.37) | CHRNA7CHRM2CHRM1CHRNA4CYP2D6 | |
| Hydrochloric Acid SCHEMBL11442910 | 0.77 | ALDH1A1 (0.40) | CHRM2CHRM1CYP2D6CHRM3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3303328-B1 | AMINOESTER DERIVATIVES | CHIESI FARM SPA (IT) | 2019-03-20 | — | — | EP | disclosed |
| US-9636336-B2 | Aminoester derivatives | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-05-02 | — | — | US | disclosed |
| US-9597323-B2 | Aminoester derivatives | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-03-21 | — | — | US | disclosed |
| US-9597323-B2 | Aminoester derivatives | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-03-21 | — | — | US | disclosed |
| WO-2016193244-A1 | AMINOESTER DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-12-08 | — | — | WO | disclosed |
| WO-2016193240-A1 | AMINOESTER DERIVATIVES USEFUL IN THE TREATMENT OF COPD | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-12-08 | — | — | WO | disclosed |
| US-20160346260-A1 | AMINOESTER DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-12-01 | — | — | US | disclosed |
| US-20160346260-A1 | AMINOESTER DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2016-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160346260-A1 | AMINOESTER DERIVATIVES | PDE4A, PDE4B, PDE3B | CHRNA7 103/4885CHRM2 18/4885CHRM1 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.