⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7318990 | 1.00 | — | — | |
| SCHEMBL18268167 | 0.88 | CHRNA7 (0.42) | — | |
| SCHEMBL415807 | 0.88 | CHRNA7 (0.42) | — | |
| SCHEMBL18268169 | 0.88 | CHRNA7 (0.42) | — | |
| SCHEMBL13398703 | 0.86 | TDP1 (0.39) | — | |
| Hydrochloric Acid SCHEMBL10978368 | 0.86 | CHRNA7 (0.41) | — | |
| SCHEMBL9962908 | 0.76 | — | — | |
| SCHEMBL7438188 | 0.76 | — | — | |
| SCHEMBL13398716 | 0.76 | TDP1 (0.38) | — | |
| SCHEMBL21095889 | 0.74 | SLC6A12 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE43390-E1 | Pleuromutilin derivatives as antimicrobials | GLAXOSMITHKLINE LLC (US) | 2012-05-15 | — | — | US | disclosed |
| EP-1930330-B1 | Pleuromutilin derivatives as antimicrobials | SMITHKLINE BEECHAM LTD (GB) | 2011-09-21 | — | — | EP | disclosed |
| EP-1028961-B3 | PLEUROMUTILIN DERIVATIVES AS ANTIMICROBIALS | SMITHKLINE BEECHAM PLC (GB) | 2008-12-03 | — | — | EP | disclosed |
| EP-1930330-A1 | Pleuromutilin derivatives as antimicrobials | SMITHKLINE BEECHAM PLC (GB) | 2008-06-11 | — | — | EP | disclosed |
| US-RE39128-E1 | ANTIBACTERIA DRUG; RESPIRATORY SYSTEM DISORDERS; OTITIS | SMITHKLINE BEECHAM P.L.C. (GB) | 2006-06-13 | — | — | US | disclosed |
| EP-1028961-B1 | PLEUROMUTILIN DERIVATIVES AS ANTIMICROBIALS | SMITHKLINE BEECHAM PLC (GB) | 2004-09-29 | — | — | EP | disclosed |
| EP-1452534-A1 | PLEUROMUTLIN DERIVATIVES AS ANTIMICROBIALS | SMITHKLINE BEECHAM PLC (GB) | 2004-09-01 | — | — | EP | disclosed |
| US-6281226-B1 | Pleuromutilin derivatives as antimicrobials | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-08-28 | — | — | US | disclosed |
| EP-1028961-A1 | PLEUROMUTILIN DERIVATIVES AS ANTIMICROBIALS | SMITHKLINE BEECHAM PLC (GB) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999021855-A1 | PLEUROMUTILIN DERIVATIVES AS ANTIMICROBIALS | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-05-06 | — | — | WO | disclosed |