Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 4/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 6/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3567709 | 0.81 | F11 (0.41) | F11SSTR4FFAR4ADRA1A | |
| SCHEMBL12099245 | 0.76 | F11 (0.34) | F11 | |
| SCHEMBL18274666 | 0.76 | F11 (0.35) | F11HCRTR1HCRTR2GRM1CYP2D6 | |
| SCHEMBL16553717 | 0.76 | NPSR1 (0.36) | F11 | |
| SCHEMBL19990349 | 0.76 | OPRM1 (0.49) | F11 | |
| SCHEMBL4812083 | 0.74 | F11 (0.39) | F11HSD11B1 | |
| SCHEMBL16553749 | 0.74 | F11 (0.35) | F11CYP2D6 | |
| SCHEMBL16554012 | 0.74 | F11 (0.35) | F11ADRA1AADRA1DADRA1BCYP2D6 | |
| SCHEMBL16553927 | 0.73 | ADRA1D (0.35) | F11ADRA1AADRA1DADRA1BCYP2D6 | |
| SCHEMBL3555626 | 0.73 | POLB (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1729772-B1 | HETEROARYL PIPERIDINE GLYCINE TRANSPORTER INHIBITORS | MERCK SHARP & DOHME (US) | 2016-12-07 | — | — | EP | disclosed |