Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 3/20 | 0.51 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.41 |
| ▸ | CPB2 | Q96IY4 | 10/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18280228 | 1.00 | FOLH1 (0.51) | FOLH1SLC6A5CPB2GSRCA1 | |
| SCHEMBL16861162 | 0.85 | FOLH1 (0.51) | FOLH1SLC6A5CPB2GSRCA1 | |
| SCHEMBL16861161 | 0.85 | FOLH1 (0.51) | FOLH1SLC6A5CPB2GSRCA1 | |
| SCHEMBL27611756 | 0.81 | FOLH1 (0.54) | FOLH1SLC6A5CPB2GSRCA1 | |
| SCHEMBL28456990 | 0.80 | FOLH1 (0.60) | FOLH1SLC6A5CPB2GSRCA1 | |
| SCHEMBL17509712 | 0.80 | SLC6A5 (0.55) | FOLH1SLC6A5CA1CA2 | |
| SCHEMBL8639355 | 0.80 | SLC6A5 (0.55) | FOLH1SLC6A5CA1CA2 | |
| SCHEMBL9698704 | 0.79 | FOLH1 (0.58) | FOLH1SLC6A5CPB2GSRCA1 | |
| SCHEMBL3435138 | 0.79 | FOLH1 (0.58) | FOLH1SLC6A5CPB2GSRCA1 | |
| SCHEMBL16861145 | 0.79 | FOLH1 (0.51) | FOLH1SLC6A5CPB2GSRCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4490202-A1 | CYCLOPEPTIBODIES AND USES THEREOF | University of Rochester (US) | 2025-01-15 | — | — | EP | claimed |
| WO-2023173084-A9 | CYCLOPEPTIBODIES AND USES THEREOF | UNIVERSITY OF ROCHESTER (US) | 2023-12-14 | — | — | WO | claimed |
| WO-2023173084-A1 | CYCLOPEPTIBODIES AND USES THEREOF | UNIVERSITY OF ROCHESTER (US) | 2023-09-14 | — | — | WO | claimed |
| EP-4122945-A1 | METHODS AND COMPOSITIONS FOR RIBOSOMAL SYNTHESIS OF MACROCYCLIC PEPTIDES | University of Rochester (US) | 2023-01-25 | — | — | EP | claimed |
| US-20200299675-A1 | Methods and Compositions for Display of Macrocyclic Peptides | UNIVERSITY OF ROCHESTER | 2020-09-24 | — | — | US | claimed |
| US-10544191-B2 | Methods and compositions for ribosomal synthesis of macrocyclic peptides | UNIVERSITY OF ROCHESTER (US) | 2020-01-28 | — | — | US | claimed |
| US-20160355552-A1 | METHODS AND COMPOSITIONS FOR RIBOSOMAL SYNTHESIS OF MACROCYCLIC PEPTIDES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-12-08 | — | — | US | claimed |
| US-12359192-B2 | Methods and compositions for display of macrocyclic peptides | UNIVERSITY OF ROCHESTER (US) | 2025-07-15 | — | — | US | disclosed |
| WO-2023173084-A9 | CYCLOPEPTIBODIES AND USES THEREOF | UNIVERSITY OF ROCHESTER (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023173084-A1 | CYCLOPEPTIBODIES AND USES THEREOF | UNIVERSITY OF ROCHESTER (US) | 2023-09-14 | — | — | WO | disclosed |
| EP-4122945-A1 | METHODS AND COMPOSITIONS FOR RIBOSOMAL SYNTHESIS OF MACROCYCLIC PEPTIDES | University of Rochester (US) | 2023-01-25 | — | — | EP | disclosed |
| EP-3087088-B1 | METHODS AND COMPOSITIONS FOR RIBOSOMAL SYNTHESIS OF MACROCYCLIC PEPTIDES | UNIV ROCHESTER (US) | 2022-05-25 | — | — | EP | disclosed |
| US-20200299675-A1 | Methods and Compositions for Display of Macrocyclic Peptides | UNIVERSITY OF ROCHESTER | 2020-09-24 | — | — | US | disclosed |
| US-10544191-B2 | Methods and compositions for ribosomal synthesis of macrocyclic peptides | UNIVERSITY OF ROCHESTER (US) | 2020-01-28 | — | — | US | disclosed |
| US-20160355552-A1 | METHODS AND COMPOSITIONS FOR RIBOSOMAL SYNTHESIS OF MACROCYCLIC PEPTIDES | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12359192-B2 | Methods and compositions for display of macrocyclic peptides | NGLY1, MICA, MRPL21 | FOLH1 451/4885SLC6A5 4764/4885CPB2 196/4885 |
| US-10544191-B2 | Methods and compositions for ribosomal synthesis of macrocyclic peptides | MRPS27, MRPL21, RPLP2 | FOLH1 1164/4885SLC6A5 4811/4885CPB2 862/4885 |
| US-20160355552-A1 | METHODS AND COMPOSITIONS FOR RIBOSOMAL SYNTHESIS OF MACROCYCLIC PEPTIDES | MRPS27, MRPL21, RPLP2 | FOLH1 1164/4885SLC6A5 4811/4885CPB2 862/4885 |
| US-20200299675-A1 | Methods and Compositions for Display of Macrocyclic Peptides | SPOUT1, NGLY1, VIP | FOLH1 555/4885SLC6A5 4513/4885CPB2 296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.