Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.45 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.45 |
| ▸ | CCR1 | P32246 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20007281 | 0.77 | TRPV4 (0.52) | ALDH1A1TRPV4CYP2C19 | |
| SCHEMBL2956822 | 0.73 | CCR1 (0.65) | KDM4EGAAALDH1A1MBTD1L3MBTL3 | |
| SCHEMBL2963267 | 0.72 | KDM4E (0.67) | KDM4EGAAALDH1A1CCR1CYP2C19 | |
| SCHEMBL15232808 | 0.72 | KDM4E (0.55) | HSD11B1KDM4EGAAALDH1A1MEN1 | |
| SCHEMBL17007496 | 0.71 | CYP2D6 (0.53) | KDM4EALDH1A1MEN1KMT2ACCR1 | |
| SCHEMBL17007475 | 0.71 | DHCR7 (0.50) | ALDH1A1MEN1KMT2ACCR1HPGD | |
| SCHEMBL17007472 | 0.70 | MEN1 (0.71) | KDM4EGAAALDH1A1MEN1KMT2A | |
| SCHEMBL2955805 | 0.70 | ALDH1A1 (0.61) | GAAALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL2955803 | 0.70 | ALDH1A1 (0.61) | GAAALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL2953452 | 0.69 | ALDH1A1 (0.77) | GAAALDH1A1MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160355514-A1 | PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES | VALO EARLY DISCOVERY, INC. | 2016-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160355514-A1 | PYRIDINYL AND PYRIMIDINYL SULFOXIDE AND SULFONE DERIVATIVES | TPMT, TYMS, TYMP | HSD11B1 3828/4885KDM4E 2902/4885GAA 1392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.