Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.52 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.43 |
| ▸ | FEN1 | P39748 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | FABP1 | P07148 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | COMT | P21964 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18280685 | 0.77 | HSD11B1 (0.50) | TRPV4CYP2C19ALDH1A1 | |
| SCHEMBL20007774 | 0.74 | TRPV4 (0.55) | TRPV4ALOX5APFEN1FABP1ALDH1A1 | |
| SCHEMBL15918113 | 0.73 | EPHX2 (0.51) | TRPV4ALOX5APFEN1CYP3A4CYP2C19 | |
| SCHEMBL15916093 | 0.73 | EPHX2 (0.51) | TRPV4ALOX5APFEN1CYP3A4CYP2C19 | |
| SCHEMBL15917892 | 0.73 | EPHX2 (0.51) | TRPV4ALOX5APFEN1CYP3A4CYP2C19 | |
| SCHEMBL16582298 | 0.73 | ALOX5AP (0.51) | ALOX5APFEN1CYP3A4CYP2C19CYP19A1 | |
| SCHEMBL16582321 | 0.73 | ALOX5AP (0.51) | ALOX5APFEN1CYP3A4CYP2C19CYP19A1 | |
| SCHEMBL23614005 | 0.72 | PDE4D (0.37) | TRPV4CYP3A4 | |
| SCHEMBL20007694 | 0.71 | CYP3A4 (0.53) | TRPV4ALOX5APFEN1CYP3A4CYP2C19 | |
| SCHEMBL20007287 | 0.71 | TRPV4 (0.55) | TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |