Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.72 |
| ▸ | LTA4H | P09960 | 10/20 | 0.63 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL182574 | 0.85 | HRH3 (0.69) | HRH3LTA4H | |
| SCHEMBL255201 | 0.84 | LTA4H (0.86) | HRH3LTA4H | |
| Ammonia Solution, Strong SCHEMBL264615 | 0.82 | LTA4H (0.83) | HRH3LTA4H | |
| SCHEMBL5870409 | 0.82 | LTA4H (0.83) | HRH3LTA4HKCNH2 | |
| SCHEMBL3951411 | 0.82 | LTA4H (0.83) | HRH3LTA4HKCNH2 | |
| SCHEMBL5943693 | 0.82 | HRH3 (0.60) | HRH3LTA4HKCNH2 | |
| SCHEMBL8109834 | 0.81 | TMEM97 (0.68) | HRH3LTA4HTMEM97SIGMAR1 | |
| SCHEMBL6943925 | 0.81 | TMEM97 (0.68) | HRH3LTA4HTMEM97SIGMAR1 | |
| SCHEMBL8693762 | 0.81 | TMEM97 (0.68) | LTA4HTMEM97SIGMAR1 | |
| Bromide SCHEMBL4827747 | 0.80 | LTA4H (0.81) | HRH3LTA4HKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049502-B1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-04 | — | — | EP | disclosed |