SCHEMBL1828293

SCHEMBL1828293

CSCC[C@H](N)C(=O)OC(=O)[C@@H](N)CC(N)=O

nearest known ligand 0.52

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
METAP2 P50579 1/20 0.35
METAP1 P53582 1/20 0.35
MARS1 P56192 9/20 0.35
RNPEP Q9H4A4 1/20 0.35
ANPEP P15144 1/20 0.33
ENPEP Q07075 1/20 0.33
BHMT Q93088 1/20 0.33
NOS2 P35228 2/20 0.32
NOS3 P29474 1/20 0.32
NOS1 P29475 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20996747 0.89 RNPEP (0.42) METAP2METAP1MARS1RNPEPANPEP
SCHEMBL162031 0.89 RNPEP (0.42) METAP2METAP1MARS1RNPEPANPEP
SCHEMBL5617582 0.89 RNPEP (0.42) METAP2METAP1MARS1RNPEPANPEP
SCHEMBL6045793 0.89 RNPEP (0.42) METAP2METAP1MARS1RNPEPANPEP
SCHEMBL4615397 0.86 ALOX15 (0.46) METAP2METAP1MARS1RNPEPANPEP
SCHEMBL108278 0.86 METAP2 (0.35) METAP2METAP1MARS1RNPEPANPEP
Hydrochloric Acid SCHEMBL8954857 0.85 METAP2 (0.35) METAP2METAP1MARS1RNPEPANPEP
SCHEMBL997468 0.84 RNPEP (0.38) METAP2METAP1MARS1RNPEPANPEP
SCHEMBL1352749 0.83 SLC7A5 (0.42) METAP2METAP1MARS1RNPEPANPEP
SCHEMBL11531701 0.82 RNPEP (0.37) METAP2METAP1MARS1RNPEPANPEP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0514509-B1 COMPOSITION AND ITS PREPARATION PROCESS USING ANTIGEN CONJUGATED TO ENZYMATIC ACTIVITY FOR IMMUNOLOGICAL DIAGNOSIS AND CHAGAS' DISEASE IMMUNOLOGICAL DIAGNOSIS KITS, FOR INDIVIDUAL AND EPIDEMIOLOGICAL APPLICATION, BASED ON THAT COMPOSITION FUNDACAO OSWALDO CRUZ (BR) 2000-09-20 EP claimed
CN-113557292-B Mutant proteases 花王株式会社 2023-10-20 CN disclosed
CN-113557292-A Mutant proteases 花王株式会社 2021-10-26 CN disclosed
EP-2729570-A2 REAGENT USABLE FOR THE ISOLATION AND/OR PURIFICATION OF NUCLEIC ACIDS Qiagen GmbH (DE) 2014-05-14 EP disclosed
EP-1466924-B9 Synthetic peptide vaccines for HIV: the CBD epitope as an effective immunogen to elicit broadly neutralizing antibodies against HIV PASTEUR INSTITUT (FR) 2013-06-19 EP disclosed
WO-2013004710-A2 REAGENT USABLE FOR THE ISOLATION AND/OR PURIFICATION OF NUCLEIC ACIDS QIAGEN GMBH (DE) 2013-01-10 WO disclosed
US-8173767-B2 Synthetic peptide vaccines for HIV: the CBD epitope as an effective immunogen to elicit broadly neutralizing antibodies against HIV INSTITUT PASTEUR (FR) 2012-05-08 US disclosed
EP-1466924-B1 Synthetic peptide vaccines for HIV: the CBD epitope as an effective immunogen to elicit broadly neutralizing antibodies against HIV PASTEUR INSTITUT (FR) 2011-05-04 EP disclosed
US-20100247618-A1 Novel synthetic peptide vaccines for HIV: the CBD epitope as an effective immunogen to elicit broadly neutralizing antibodies against HIV INSTITUT PASTEUR 2010-09-30 US disclosed
US-7364744-B2 Synthetic peptide vaccines for HIV: the CBD epitope as an effective immunogen to elicit broadly neutralizing antibodies against HIV INSTITUT PASTEUR (FR) 2008-04-29 US disclosed
US-20050124540-A1 Novel synthetic peptide vaccines for HIV: the CBD epitope as an effective immunogen to elicit broadly neutralizing antibodies against HIV CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2005-06-09 US disclosed
EP-1466924-A1 Synthetic peptide vaccines for HIV: the CBD epitope as an effective immunogen to elicit broadly neutralizing antibodies against HIV INSTITUT PASTEUR (FR) 2004-10-13 EP disclosed
EP-0514509-B1 COMPOSITION AND ITS PREPARATION PROCESS USING ANTIGEN CONJUGATED TO ENZYMATIC ACTIVITY FOR IMMUNOLOGICAL DIAGNOSIS AND CHAGAS' DISEASE IMMUNOLOGICAL DIAGNOSIS KITS, FOR INDIVIDUAL AND EPIDEMIOLOGICAL APPLICATION, BASED ON THAT COMPOSITION FUNDACAO OSWALDO CRUZ (BR) 2000-09-20 EP disclosed
EP-0853667-A2 BONE STIMULATING FACTOR Gensci Regeneration Sciences Inc. (CA) 1998-07-22 EP disclosed
WO-1997012036-A2 BONE STIMULATING FACTOR GENSCI REGENERATION SCIENCES INC. (CA) 1997-04-03 WO disclosed