Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.49 |
| ▸ | TSHR | P16473 | 6/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | USP2 | O75604 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HBB | P68871 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL182803 | 0.72 | MAP4K4 (0.54) | LMNACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL24010781 | 0.70 | DOT1L (0.63) | HPGDALDH1A1HSD17B10KDM4EGLA | |
| SCHEMBL25828236 | 0.66 | APP (0.51) | LMNACYP1A2CYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL4779108 | 0.66 | IDO1 (0.43) | LMNACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL2993281 | 0.65 | HSP90AA1 (0.44) | LMNACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6182383 | 0.65 | EGFR (0.56) | EGFRKDRRETKITCSF1R | |
| SCHEMBL10970553 | 0.65 | MAP4K4 (0.51) | LMNACYP1A2CYP3A4ALDH1A1HSD17B10 | |
| SCHEMBL8976460 | 0.65 | EGFR (0.53) | LMNACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL196440 | 0.65 | MGAM (0.55) | LMNACYP3A4HPGDALDH1A1HSD17B10 | |
| SCHEMBL1264612 | 0.64 | KIT (0.60) | EGFRKDRKITCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049502-B1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-04 | — | — | EP | claimed |