Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 10/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.48 |
| ▸ | LMNA | P02545 | 6/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.48 |
| ▸ | USP2 | O75604 | 6/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL183384 | 0.83 | PIK3CD (0.61) | MAP4K4CYP1A2CYP3A4ALDH1A1CLK4 | |
| SCHEMBL182841 | 0.72 | LMNA (0.49) | MAP4K4CYP1A2CYP3A4ALDH1A1CLK4 | |
| SCHEMBL15587440 | 0.71 | MAP4K4 (1.00) | MAP4K4IRAK4 | |
| SCHEMBL183242 | 0.71 | PIK3CD (0.58) | MAP4K4CYP1A2CYP3A4ALDH1A1CLK4 | |
| SCHEMBL2980619 | 0.69 | CYP11B1 (0.54) | MAP4K4HSD17B10MAPK1KITKDM4E | |
| SCHEMBL3120401 | 0.68 | MAP4K4 (0.56) | MAP4K4CYP1A2CYP3A4ALDH1A1CLK4 | |
| SCHEMBL183106 | 0.67 | PIK3CD (0.65) | MAP4K4CYP1A2CYP3A4ALDH1A1CLK4 | |
| SCHEMBL2204306 | 0.67 | HPGDS (0.60) | CYP1A2CYP3A4ALDH1A1CLK4LMNA | |
| SCHEMBL18462160 | 0.67 | CYP11B2 (0.53) | MAP4K4CYP1A2RAF1 | |
| SCHEMBL182982 | 0.66 | PIK3CD (0.61) | MAP4K4CYP1A2CYP3A4ALDH1A1CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049502-B1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-04 | — | — | EP | claimed |