Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.75 |
| ▸ | HPGD | P15428 | 1/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | NAMPT | P43490 | 2/20 | 0.67 |
| ▸ | PREP | P48147 | 2/20 | 0.64 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.63 |
| ▸ | CA12 | O43570 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
| ▸ | CA7 | P43166 | 1/20 | 0.60 |
| ▸ | CA9 | Q16790 | 1/20 | 0.60 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | GRM5 | P41594 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13753548 | 0.96 | PREP (0.70) | GAAHPGDALDH1A1NAMPTPREP | |
| SCHEMBL10720276 | 0.87 | GAA (1.00) | GAAHPGDALDH1A1NAMPTHSD11B1 | |
| SCHEMBL3643262 | 0.83 | GAA (0.80) | GAAHPGDALDH1A1NAMPTHSD11B1 | |
| SCHEMBL14825254 | 0.82 | HSD11B1 (0.77) | GAAHPGDALDH1A1NAMPTHSD11B1 | |
| SCHEMBL18286158 | 0.81 | PREP (0.58) | GAAALDH1A1NAMPTPREPHSD11B1 | |
| SCHEMBL3701309 | 0.80 | NAMPT (1.00) | GAAHPGDALDH1A1NAMPT | |
| SCHEMBL16254905 | 0.80 | GAA (0.84) | GAAHPGDALDH1A1NAMPTHSD11B1 | |
| SCHEMBL788241 | 0.80 | GAA (0.84) | GAAHPGDALDH1A1NAMPTHSD11B1 | |
| SCHEMBL16254982 | 0.80 | HPGD (0.84) | GAAHPGDALDH1A1NAMPTHSD11B1 | |
| SCHEMBL2729249 | 0.80 | GAA (0.84) | GAAHPGDALDH1A1NAMPTHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3303291-A1 | ROR GAMMA (ROR ) MODULATORS | Lead Pharma Holding B.V. (NL) | 2018-04-11 | — | — | EP | claimed |
| WO-2016193452-A1 | ROR GAMMA (RORγ) MODULATORS | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2016-12-08 | — | — | WO | claimed |