Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 2/20 | 0.58 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.52 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.52 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.51 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.51 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18283321 | 0.96 | PREP (0.62) | PREPNAMPTPARP14PARP10AVPR1A | |
| SCHEMBL27261597 | 0.95 | PREP (0.55) | PREPNAMPTPARP14PARP10TRPC3 | |
| SCHEMBL8596155 | 0.84 | PARP14 (0.62) | PARP14PARP10TRPC3TRPC6ALDH1A1 | |
| SCHEMBL18286135 | 0.82 | HSP90AA1 (0.52) | PREPAVPR1AALDH1A1MEN1KMT2A | |
| SCHEMBL18286153 | 0.81 | GAA (0.75) | PREPNAMPTAVPR1AALDH1A1GAA | |
| SCHEMBL18275063 | 0.80 | RORC (0.59) | HSD11B1MEN1KMT2A | |
| SCHEMBL18275345 | 0.77 | HSD11B1 (0.56) | ALDH1A1GAAHSD11B1MEN1KMT2A | |
| SCHEMBL9336982 | 0.77 | RIPK1 (0.63) | PARP14PARP10TRPC3TRPC6PRMT5 | |
| SCHEMBL19971958 | 0.77 | MAPT (0.47) | PREPALDH1A1GAAMEN1KMT2A | |
| SCHEMBL13753548 | 0.77 | PREP (0.70) | PREPNAMPTALDH1A1GAAHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3303291-A1 | ROR GAMMA (ROR ) MODULATORS | Lead Pharma Holding B.V. (NL) | 2018-04-11 | — | — | EP | claimed |
| WO-2016193452-A1 | ROR GAMMA (RORγ) MODULATORS | LEAD PHARMA CEL MODELS IP B.V. (NL) | 2016-12-08 | — | — | WO | claimed |