Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 17/20 | 0.58 |
| ▸ | MPEG1 | Q2M385 | 11/20 | 0.58 |
| ▸ | XIAP | P98170 | 2/20 | 0.58 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | PTGES | O14684 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365320 | 0.85 | ALOX5 (0.65) | ALOX5MPEG1XIAPGPR84ALDH1A1 | |
| SCHEMBL29911486 | 0.83 | ALOX5 (0.64) | ALOX5MPEG1XIAPGPR84ALDH1A1 | |
| SCHEMBL14507682 | 0.81 | ALOX5 (0.62) | ALOX5MPEG1XIAPGPR84ALDH1A1 | |
| SCHEMBL5554107 | 0.78 | ALOX5 (0.58) | ALOX5MPEG1XIAPGPR84ALDH1A1 | |
| Rapanone SCHEMBL2311835 | 0.74 | ALOX5 (1.00) | ALOX5MPEG1XIAPGPR84ALDH1A1 | |
| SCHEMBL12757276 | 0.74 | ALOX5 (1.00) | ALOX5MPEG1XIAPGPR84ALDH1A1 | |
| Embelin SCHEMBL148744 | 0.74 | ALOX5 (1.00) | ALOX5MPEG1XIAPGPR84ALDH1A1 | |
| SCHEMBL5671789 | 0.73 | ALDH1A1 (0.44) | ALOX5MPEG1XIAPGPR84ALDH1A1 | |
| SCHEMBL17123718 | 0.72 | ALOX5 (0.73) | ALOX5MPEG1XIAPGPR84ALDH1A1 | |
| SCHEMBL3273093 | 0.72 | ALOX5 (0.55) | ALOX5MPEG1XIAPGPR84ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10858358-B2 | S1PR2 antagonists and uses therefor | DALHOUSIE UNIVERSITY (CA) | 2020-12-08 | — | — | US | disclosed |
| US-20200347058-A1 | S1PR2 ANTAGONISTS AND USES THEREFOR | DALHOUSIE UNIVERSITY (CA) | 2020-11-05 | — | — | US | disclosed |
| US-10487082-B2 | S1PR2 antagonists and uses therefor | DALHOUSIE UNIVERSITY (CA) | 2019-11-26 | — | — | US | disclosed |
| US-20190169187-A1 | S1PR2 ANTAGONISTS AND USES THEREFOR | DALHOUSIE UNIVERSITY (CA) | 2019-06-06 | — | — | US | disclosed |
| US-20190127372-A1 | S1PR2 ANTAGONISTS AND USES THEREFOR | DALHOUSIE UNIVERSITY (CA) | 2019-05-02 | — | — | US | disclosed |
| US-20180141942-A1 | S1PR2 ANTAGONISTS AND USES THEREFOR | DALHOUSIE UNIVERSITY (CA) | 2018-05-24 | — | — | US | disclosed |
| EP-3298014-A1 | S1PR2 ANTAGONISTS AND USES THEREFOR | Dalhousie University (CA) | 2018-03-28 | — | — | EP | disclosed |
| WO-2016191872-A1 | S1PR2 ANTAGONISTS AND USES THEREFOR | DALHOUSIE UNIVERSITY (CA) | 2016-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10858358-B2 | S1PR2 antagonists and uses therefor | S1PR2, S1PR4, S1PR1 | ALOX5 1278/4885MPEG1 1108/4885XIAP 2853/4885 |
| US-20190127372-A1 | S1PR2 ANTAGONISTS AND USES THEREFOR | S1PR2, S1PR4, S1PR1 | ALOX5 1193/4885MPEG1 2296/4885XIAP 2533/4885 |
| US-20190169187-A1 | S1PR2 ANTAGONISTS AND USES THEREFOR | S1PR2, S1PR4, S1PR3 | ALOX5 965/4885MPEG1 973/4885XIAP 2876/4885 |
| US-20200347058-A1 | S1PR2 ANTAGONISTS AND USES THEREFOR | S1PR2, S1PR4, S1PR1 | ALOX5 1193/4885MPEG1 2296/4885XIAP 2533/4885 |
| US-20180141942-A1 | S1PR2 ANTAGONISTS AND USES THEREFOR | S1PR2, S1PR4, S1PR1 | ALOX5 1193/4885MPEG1 2296/4885XIAP 2533/4885 |
| US-10487082-B2 | S1PR2 antagonists and uses therefor | S1PR2, S1PR4, S1PR3 | ALOX5 965/4885MPEG1 973/4885XIAP 2876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.