Embelin

Embelin

SCHEMBL148744

CCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 17/20 1.00
MPEG1 Q2M385 11/20 1.00
XIAP P98170 5/20 1.00
GPR84 Q9NQS5 2/20 1.00
KDM4E B2RXH2 1/20 1.00
MEN1 O00255 1/20 1.00
PTGES O14684 1/20 1.00
USP2 O75604 1/20 1.00
ALDH1A1 P00352 1/20 1.00
TP53 P04637 1/20 1.00
CYP2D6 P10635 1/20 1.00
MAPT P10636 1/20 1.00
CYP2C9 P11712 1/20 1.00
HPGD P15428 1/20 1.00
ALOX15 P16050 1/20 1.00
ALOX12 P18054 1/20 1.00
MAPK1 P28482 1/20 1.00
CYP2C19 P33261 1/20 1.00
KMT2A Q03164 1/20 1.00
KAT2B Q92831 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12757276 1.00 ALOX5 (1.00) ALOX5MPEG1XIAPGPR84KDM4E
Rapanone SCHEMBL2311835 1.00 ALOX5 (1.00) ALOX5MPEG1XIAPGPR84KDM4E
SCHEMBL6410428 0.98 ALOX5 (0.97) ALOX5MPEG1XIAPGPR84KDM4E
Embelin SCHEMBL4653231 0.94 ALOX5 (0.88) ALOX5MPEG1XIAPGPR84KDM4E
SCHEMBL9580649 0.91 ALOX5 (0.83) ALOX5MPEG1XIAPGPR84KDM4E
Embelin SCHEMBL21905447 0.90 ALOX5 (0.81) ALOX5MPEG1XIAPGPR84KDM4E
SCHEMBL12830675 0.85 ALOX5 (0.74) ALOX5MPEG1XIAPGPR84KDM4E
SCHEMBL17123718 0.85 ALOX5 (0.73) ALOX5MPEG1XIAPGPR84KDM4E
SCHEMBL19236537 0.83 ALOX5 (0.71) ALOX5MPEG1XIAPGPR84KDM4E
SCHEMBL11148794 0.81 ALOX5 (0.68) ALOX5MPEG1XIAPGPR84KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1752 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250092269-A1 ANTI-BIOFOULING COMPOSITION Montana Technological University 2025-03-20 US claimed
WO-2025049793-A1 SOLID COMPOSITIONS FOR PRODUCTION OF MICELLES FOR DRUG DELIVERY WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2025-03-06 WO claimed
EP-4507781-A1 DEVICE FOR TREATING A TISSUE PORTION OF A HUMAN OR ANIMAL Klose, Thomas (DE) 2025-02-19 EP claimed
WO-2025032553-A1 METHODS OF TREATING INNER EAR FIBROSIS COCHLEAR LIMITED (AU) 2025-02-13 WO claimed
US-12150969-B2 Synthetically enveloped virus University of Pittsburgh—of the Commonwealth System of Higher Education (US) 2024-11-26 US claimed
CN-118993869-A Marine fungus-derived benzoquinone derivative embelin A and preparation method and application thereof 中国科学院南海海洋研究所 2024-11-22 CN claimed
CN-118795124-A Biomarker for predicting aging and application thereof 深圳华大生命科学研究院 2024-10-18 CN claimed
US-20240315965-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2024-09-26 US claimed
US-20240307337-A1 Method Of Treatment Of Obesity QUEEN MARY UNIVERSITY OF LONDON (GB) 2024-09-19 US claimed
WO-2024175554-A1 TRAIL AGONISTS FOR USE IN THE TREATMENT OF CANCER IN PATIENTS HAVING AN ACTIVATING ALTERATION OF FGFR3 INSTITUT CURIE (FR) 2024-08-29 WO claimed
US-20060069042-A1 Cytochrome P450 2C9 inhibitors NATIONAL DEFENSE MEDICAL CENTER (TW) 2006-03-30 US claimed
WO-2005092326-A1 SMALL MOLECULE ANTAGONISTS OF XIAP FAMILY PROTEINS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2005-10-06 WO claimed
US-20040152760-A1 Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases PROTAMED, INC. 2004-08-05 US claimed
JP-2003532634-A 2003-11-05 JP claimed
EP-1244435-A2 POLYHYDROXYLATED AROMATIC COMPOUNDS FOR THE TREATMENT OF AMYLOIDOSIS AND $g(a)-SYNUCLEIN FIBRIL DISEASES Proteotech Inc. (US) 2002-10-02 EP claimed
US-20010047032-A1 Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases PROTAMED, INC. 2001-11-29 US claimed
WO-2001049281-A2 POLYHYDROXYLATED AROMATIC COMPOUNDS FOR THE TREATMENT OF AMYLOIDOSIS AND α-SYNUCLEIN FIBRIL DISEASES PROTEOTECH, INC. (US) 2001-07-12 WO claimed
CN-1294519-A Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient INPHARMA SA (CH) 2001-05-09 CN claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12150969-B2 Synthetically enveloped virus PIGS, LIPG, FURIN ALOX5 1873/4885MPEG1 829/4885XIAP 1888/4885
US-20010047032-A1 Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases SNCA, PARK7, HTT ALOX5 1538/4885MPEG1 2104/4885XIAP 352/4885
US-20040152760-A1 Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases SNCA, PARK7, HTT ALOX5 1538/4885MPEG1 2104/4885XIAP 352/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.