Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | NOS1 | P29475 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.44 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.43 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3293939 | 0.93 | MAPT (0.49) | MAPTPOLBLMNANOS1CYP3A4 | |
| Biphenyl SCHEMBL28799571 | 0.84 | CYP19A1 (0.48) | MAPTNPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL9041848 | 0.82 | MEN1 (0.49) | MAPTPOLBLMNANOS1CYP3A4 | |
| SCHEMBL3829978 | 0.80 | TSHR (0.56) | MAPTPOLBLMNANOS1CYP3A4 | |
| SCHEMBL14010958 | 0.79 | MAPT (0.53) | MAPTPOLBLMNANOS1CYP3A4 | |
| SCHEMBL30095409 | 0.79 | MAPT (0.53) | MAPTPOLBLMNANOS1CYP3A4 | |
| SCHEMBL28122579 | 0.77 | TSHR (0.59) | MAPTPOLBLMNANOS1CYP3A4 | |
| Isoquinoline SCHEMBL13822661 | 0.76 | ALDH1A1 (0.57) | MAPTPOLBLMNANPC1RAB9A | |
| SCHEMBL14486805 | 0.75 | ALDH1A1 (0.65) | MAPTPOLBLMNANOS1MAOB | |
| SCHEMBL57616 | 0.74 | LMNA (0.56) | MAPTLMNANOS1CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107602466-A | A kind of preparation method of Nuo get Si Ta medicines | 孙婷婷 | 2018-01-19 | — | — | CN | claimed |
| CN-102875465-A | Method for preparing 7-bromoisoquinoline | UNIV SHANGHAI | 2013-01-16 | — | — | CN | claimed |
| US-7732534-B2 | Polymers functionalized with nitro compounds | BRIDGESTONE CORPORATION (JP) | 2010-06-08 | — | — | US | claimed |
| US-20080051519-A1 | Polymers functionalized with nitro compounds | BRIDGESTONE CORPORATION (JP) | 2008-02-28 | — | — | US | claimed |
| US-20080051552-A1 | Polymers functionalized with nitro compounds | BRIDGESTONE CORPORATION | 2008-02-28 | — | — | US | claimed |
| CN-106083719-B | The method for preparing isoquinoline compound | 菲布罗根有限公司 | 2019-10-18 | — | — | CN | disclosed |
| CN-110294742-A | And ring class ASK1 inhibitor and its application | 山东轩竹医药科技有限公司 | 2019-10-01 | — | — | CN | disclosed |
| CN-107602466-A | A kind of preparation method of Nuo get Si Ta medicines | 孙婷婷 | 2018-01-19 | — | — | CN | disclosed |
| EP-3219706-A1 | PROCESS FOR MAKING ISOQUINOLINE COMPOUNDS | Fibrogen, Inc. (US) | 2017-09-20 | — | — | EP | disclosed |
| US-9708269-B2 | Process for making isoquinoline compounds | FIBROGEN, INC. (US) | 2017-07-18 | — | — | US | disclosed |
| EP-2872487-B1 | PROCESS FOR MAKING ISOQUINOLINE COMPOUNDS | FIBROGEN INC (US) | 2017-04-26 | — | — | EP | disclosed |
| CN-106083719-A | The method preparing isoquinoline compound | 菲布罗根有限公司 | 2016-11-09 | — | — | CN | disclosed |
| EP-0808307-A1 | BICYCLIC ISOTHIOUREA DERIVATIVES USEFUL IN THERAPY | Astra Aktiebolag (SE) | 1997-11-26 | — | — | EP | disclosed |
| CN-1162310-A | Bicyclic amidine derivatives used in therapy | ASTRA AB (SE) | 1997-10-15 | — | — | CN | disclosed |
| EP-0759027-A1 | BICYCLIC AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHETASE | Astra Aktiebolag (SE) | 1997-02-26 | — | — | EP | disclosed |
| WO-1997006158-A1 | BICYCLIC AMIDINE DERIVATIVES USEFUL IN THERAPY | ASTRA AKTIEBOLAG (SE) | 1997-02-20 | — | — | WO | disclosed |
| WO-1996024588-A1 | BICYCLIC ISOTHIOUREA DERIVATIVES USEFUL IN THERAPY | ASTRA AKTIEBOLAG (SE) | 1996-08-15 | — | — | WO | disclosed |
| WO-1996001817-A1 | BICYCLIC AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHETASE | ASTRA AKTIEBOLAG (SE) | 1996-01-25 | — | — | WO | disclosed |
| CN-85102138-A | The preparation method of pyrimidoisoquinolinederivatives derivatives | — | 1986-04-10 | — | — | CN | disclosed |
| US-4022900-A | Compositions containing 1,2,3,4-tetrahydroisoquinolines used as hypotensive agents | MARION LABORATORIES, INC. (US) | 1977-05-10 | — | — | US | disclosed |