Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 3/20 | 0.33 |
| ▸ | FAP | Q12884 | 2/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.33 |
| ▸ | PREP | P48147 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | PEPD | P12955 | 2/20 | 0.30 |
| ▸ | XPNPEP1 | Q9NQW7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4354920 | 0.74 | RAB9A (0.33) | RAB9A | |
| SCHEMBL2804282 | 0.73 | HSD17B10 (0.39) | — | |
| SCHEMBL11036662 | 0.69 | DPP4 (0.47) | DPP4FAPDPP7DPP8DPP9 | |
| SCHEMBL1271957 | 0.68 | DPP4 (0.40) | DPP4FAPDPP7DPP8DPP9 | |
| SCHEMBL15657015 | 0.68 | TP53 (0.39) | DPP4FAPDPP7PREPDPP8 | |
| SCHEMBL137918 | 0.67 | DPP4 (0.34) | DPP4FAPDPP7PREPDPP8 | |
| SCHEMBL3692761 | 0.66 | DPP4 (0.41) | DPP4FAPDPP7DPP8DPP9 | |
| SCHEMBL30092801 | 0.64 | RAB9A (0.41) | RAB9ADPP4FAPDPP7PREP | |
| SCHEMBL3422835 | 0.64 | DPP8 (0.45) | DPP4FAPDPP7DPP8DPP9 | |
| SCHEMBL15024154 | 0.63 | ACE (0.36) | RAB9ADPP4FAPDPP7PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170226155-A1 | Smart Pro-Drugs of Serine Protease Inhibitors | TRUSTEES OF TUFTS COLLEGE (US) | 2017-08-10 | — | — | US | disclosed |
| US-9629921-B2 | Smart pro-drugs of serine protease inhibitors | TRUSTEES OF TUFTS COLLEGE (US) | 2017-04-25 | — | — | US | disclosed |
| US-20130303435-A1 | Smart Pro-Drugs of Serine Protease Inhibitors | BACH BIOSCIENCES, LLC | 2013-11-14 | — | — | US | disclosed |
| EP-2319523-A1 | Serine protease inhibitors | Trustees Of Tufts College (US) | 2011-05-11 | — | — | EP | disclosed |
| EP-2204181-A2 | Protease inhibitors | Trustees of Tufts College (US) | 2010-07-07 | — | — | EP | disclosed |
| US-20100168032-A1 | Smart Pro-Drugs of Serine Protease Inhibitors | TRUSTEES OF TUFTS COLLEGE (US) | 2010-07-01 | — | — | US | disclosed |
| US-7691967-B2 | Smart pro-drugs of serine protease inhibitors | TRUSTEES OF TUFTS COLLEGE (US) | 2010-04-06 | — | — | US | disclosed |
| US-20060089312-A1 | Protease inhibitors | BACH BIOSCIENCES, LLC | 2006-04-27 | — | — | US | disclosed |
| EP-1499336-A4 | PROTEASE INHIBITORS | TUFTS COLLEGE (US) | 2005-06-01 | — | — | EP | disclosed |
| EP-1499336-A2 | PROTEASE INHIBITORS | Trustees of Tufts College (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003092605-A9 | PROTEASE INHIBITORS | TUFTS COLLEGE (US) | 2004-04-08 | — | — | WO | disclosed |
| WO-2003092605-A2 | PROTEASE INHIBITORS | TRUSTEES OF TUFTS COLLEGE (US) | 2003-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130303435-A1 | Smart Pro-Drugs of Serine Protease Inhibitors | FAP, PREP, CTSC | RAB9A 806/4885DPP4 8/4885FAP 1/4885 |
| US-20170226155-A1 | Smart Pro-Drugs of Serine Protease Inhibitors | FAP, PREP, CTSC | RAB9A 806/4885DPP4 8/4885FAP 1/4885 |
| US-20060089312-A1 | Protease inhibitors | FAP, PREP, TFPI | RAB9A 1115/4885DPP4 14/4885FAP 1/4885 |
| US-20100168032-A1 | Smart Pro-Drugs of Serine Protease Inhibitors | FAP, PREP, CTSC | RAB9A 806/4885DPP4 8/4885FAP 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.